Key Laboratory of Molecular Genetics between Kangda College of Nanjing Medical University and Suzhou Medical College of Soochow University, Suzhou 215123, China.
Department of Basic Medicine, Kangda College of Nanjing Medical University, Lianyungang 222000, China.
Biomolecules. 2024 Jul 27;14(8):916. doi: 10.3390/biom14080916.
Metastasis is the primary cause of cancer-related death, with the dissemination and colonization of primary tumor cells at the metastatic site facilitated by various molecules and complex pathways. Understanding the biological mechanisms underlying the metastatic process is critical for the development of effective interventions. Several epigenetic modifications have been identified that play critical roles in regulating cancer metastasis. This review aims to provide a comprehensive summary of recent advances in understanding the role of epigenetic modifiers, including histone modifications, DNA methylation, non-coding RNAs, enhancer reprogramming, chromatin accessibility, and N6-methyladenosine, in metastasis-associated processes, such as epithelial-mesenchymal transition (EMT), cancer cell migration, and invasion. In particular, this review provides a detailed and in-depth description of the role of crosstalk between epigenetic regulators in tumor metastasis. Additionally, we explored the potential and limitations of epigenetics-related target molecules in the diagnosis, treatment, and prognosis of cancer metastasis.
转移是癌症相关死亡的主要原因，主要肿瘤细胞通过各种分子和复杂途径在转移部位的扩散和定植。了解转移过程中的生物学机制对于开发有效的干预措施至关重要。已经确定了几种表观遗传修饰，它们在调节癌症转移中起着关键作用。本综述旨在全面总结近年来对表观遗传修饰物（包括组蛋白修饰、DNA 甲基化、非编码 RNA、增强子重编程、染色质可及性和 N6-甲基腺苷）在转移相关过程（如上皮-间充质转化（EMT）、癌细胞迁移和侵袭）中的作用的理解的最新进展。特别是，本综述详细深入地描述了表观遗传调节剂在肿瘤转移中的相互作用。此外，我们还探讨了与癌症转移的诊断、治疗和预后相关的表观遗传相关靶分子的潜力和局限性。
