在角质形成细胞介导的突变试验中，7,8-苯并黄酮对多环芳烃依赖性诱变和细胞毒性的差异作用。
Differential effects of 7,8-benzoflavone on polycyclic aromatic hydrocarbon dependent mutagenesis and cytotoxicity in a keratinocyte cell-mediated mutation assay.
作者信息
Reiners J J
出版信息
Cancer Lett. 1985 Mar;26(2):215-20. doi: 10.1016/0304-3835(85)90029-1.
A murine keratinocyte cell-mediated mutagenesis assay was used to examine the effects of 7,8-benzoflavone (7,8-BF) on the metabolic activation of 7,12-dimethylbenz[a]anthracene (DMBA) and benzo[a]pyrene (BP) to mutagenic and cytotoxic metabolites. DMBA-dependent mutagenesis and cytotoxicity were strongly and coordinately inhibited by 7,8-BF in a concentration-dependent manner. BP-dependent mutagenesis was also strongly inhibited by 7,8-BF in a concentration-dependent manner; whereas BP-dependent cytotoxicity was relatively unaffected by 7,8-BF. Maximum inhibition of DMBA- and BP-dependent mutagenesis occurred when the cultured keratinocytes were treated with 7,8-BF immediately prior to the addition of BP or DMBA.
采用小鼠角质形成细胞介导的诱变试验，研究7,8-苯并黄酮（7,8-BF）对7,12-二甲基苯并[a]蒽（DMBA）和苯并[a]芘（BP）代谢活化为诱变和细胞毒性代谢物的影响。7,8-BF以浓度依赖性方式强烈且协同抑制DMBA依赖性诱变和细胞毒性。7,8-BF也以浓度依赖性方式强烈抑制BP依赖性诱变；而BP依赖性细胞毒性相对不受7,8-BF影响。当在添加BP或DMBA之前立即用7,8-BF处理培养的角质形成细胞时，DMBA和BP依赖性诱变受到最大抑制。
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