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大麻在肿瘤患者护理中的疗效及其抗肿瘤作用。

The Efficacy of Cannabis in Oncology Patient Care and Its Anti-Tumor Effects.

作者信息

Shalata Walid, Abu Saleh Omar, Tourkey Lena, Shalata Sondos, Neime Ala Eddin, Abu Juma'a Ali, Soklakova Arina, Tourkey Lama, Jama Ashraf Abu, Yakobson Alexander

机构信息

The Legacy Heritage Center and Dr. Larry Norton Institute, Soroka Medical Center, Beer Sheva 84105, Israel.

Medical School for International Health, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel.

出版信息

Cancers (Basel). 2024 Aug 21;16(16):2909. doi: 10.3390/cancers16162909.

DOI:10.3390/cancers16162909
PMID:39199679
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11352579/
Abstract

As the legalization of medical cannabis expands across several countries, interest in its potential advantages among cancer patients and caregivers is burgeoning. However, patients seeking to integrate cannabis into their treatment often encounter frustration when their oncologists lack adequate information to offer guidance. This knowledge gap is exacerbated by the scarcity of published literature on the benefits of medical cannabis, leaving oncologists reliant on evidence-based data disheartened. This comprehensive narrative article, tailored for both clinicians and patients, endeavors to bridge these informational voids. It synthesizes cannabis history, pharmacology, and physiology and focuses on addressing various symptoms prevalent in cancer care, including insomnia, nausea and vomiting, appetite issues, pain management, and potential anti-cancer effects. Furthermore, by delving into the potential mechanisms of action and exploring their relevance in cancer treatment, this article aims to shed light on the potential benefits and effects of cannabis in oncology.

摘要

随着医用大麻在多个国家实现合法化,癌症患者及其护理人员对其潜在益处的兴趣日益浓厚。然而,当寻求将大麻纳入治疗的患者发现他们的肿瘤学家缺乏足够信息来提供指导时,往往会感到沮丧。关于医用大麻益处的已发表文献稀缺,这加剧了这一知识差距,使得依赖循证数据的肿瘤学家感到灰心丧气。这篇为临床医生和患者量身定制的综合性叙述文章,力图填补这些信息空白。它综合了大麻的历史、药理学和生理学,并着重解决癌症护理中普遍存在的各种症状,包括失眠、恶心和呕吐、食欲问题、疼痛管理以及潜在的抗癌作用。此外,通过深入研究其潜在作用机制并探索它们在癌症治疗中的相关性,本文旨在阐明大麻在肿瘤学中的潜在益处和作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c35/11352579/2df09863b3b6/cancers-16-02909-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c35/11352579/6091f3c72a5b/cancers-16-02909-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c35/11352579/e33cb3fb6126/cancers-16-02909-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c35/11352579/2df09863b3b6/cancers-16-02909-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c35/11352579/6091f3c72a5b/cancers-16-02909-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c35/11352579/e33cb3fb6126/cancers-16-02909-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c35/11352579/2df09863b3b6/cancers-16-02909-g003.jpg

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本文引用的文献

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Could cannabinoids provide a new hope for ovarian cancer patients?大麻素类药物能否为卵巢癌患者带来新希望?
Pharmacol Res Perspect. 2023 Aug;11(4):e01122. doi: 10.1002/prp2.1122.
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Drug-Drug Interactions of Cannabidiol with Standard-of-Care Chemotherapeutics.大麻二酚与标准治疗化疗药物的药物-药物相互作用。
中国结直肠癌患者的士气低落状况及其决定因素:一项横断面研究
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Anti-Cancer Activity of Phytocannabinoids: Molecular Mechanisms and Potential in the Fight against Ovarian Cancer and Stem Cells.植物大麻素的抗癌活性:分子机制及其在对抗卵巢癌和干细胞方面的潜力
Cancers (Basel). 2022 Sep 1;14(17):4299. doi: 10.3390/cancers14174299.
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