Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, UK.
Pharmacol Res Perspect. 2023 Aug;11(4):e01122. doi: 10.1002/prp2.1122.
It is known that gynecological cancers remain a worldwide problem and as shown by the statistics, there is a need for new gynecological cancer treatments. Cannabinoids, the pharmacologically active compounds of the Cannabis sativa plant, have been used for many centuries by individuals as a symptomatic treatment to alleviate pain, nausea, vomiting, and to help stimulate appetite. Research has revealed that cannabinoids also exert anti-cancer activity such as anti-proliferative and pro-apoptotic effects through a variety of mechanisms. There is significant value in the development of these compounds as anti-cancer therapies in clinical practice as they do not produce the typical toxic side effects that exist with conventional therapies and recent clinical trials have shown their great tolerability by patients at high doses. Cannabinoids can induce psychoactive effects that could limit their progression. Therefore, non-psychoactive cannabinoids are attracting pharmacological interest due to their inability to produce psychological effects. Recent studies have focussed on non-psychoactive cannabinoids in ovarian cancer and have revealed promising pre-clinical results that indicate that these compounds may have potential benefits in the treatment of these cancers. However, there are still unanswered questions and research gaps that need to be addressed. This review summarizes the current understanding of this topic and identifies the current gaps in knowledge that provide a useful direction for future work.
已知妇科癌症仍然是一个全球性的问题，正如统计数据所示，需要新的妇科癌症治疗方法。大麻素是大麻植物中具有药理活性的化合物，几个世纪以来，个体一直将其用作缓解疼痛、恶心、呕吐和帮助刺激食欲的对症治疗方法。研究表明，大麻素还通过多种机制发挥抗癌活性，如抗增殖和促凋亡作用。这些化合物在临床实践中作为抗癌疗法具有重要价值，因为它们不会产生常规疗法存在的典型毒性副作用，最近的临床试验表明，患者在高剂量下具有很好的耐受性。大麻素会引起可能会限制其发展的精神活性作用。因此，由于不能产生心理作用，非精神活性大麻素引起了药理学的兴趣。最近的研究集中在卵巢癌的非精神活性大麻素上，并且已经揭示了有希望的临床前结果，表明这些化合物在治疗这些癌症方面可能具有潜在的益处。然而，仍有一些未解决的问题和研究空白需要解决。这篇综述总结了对这一主题的当前理解，并确定了目前知识空白，为未来的工作提供了有用的方向。
