Janvier Adélaïde, Maziere Marie, Rodrigues Célia F, Lobo Ana Paula, Rompante Paulo
Dental Sciences, University Institute of Health Sciences (IUCS-CESPU), 4585-116 Gandra, Portugal.
UNIPRO-Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS-CESPU), 4585-116 Gandra, Portugal.
Biomedicines. 2024 Aug 2;12(8):1735. doi: 10.3390/biomedicines12081735.
Dental caries is the most common oral disease in the world. When treatable, the drilling method continues to be used. This technique has its disadvantages because it is invasive and nonspecific. Chemomechanical carious tissue removal agents (CCRAs) such as Carisolv™ or Papacarie are non-invasive products that allow for the specific elimination of infected dentin. On the other hand, cariogenic bacteria are largely responsible for the initiation and development of lesions.
The aim is to analyze whether CCRAs have a relevant antimicrobial effect on cariogenic bacteria.
A bibliographic search strategy was carried out in online databases using PRISMA 2020. The evaluation of the antibacterial efficacy of CCRAs was carried out through the analysis of the reduction in CFUs of cariogenic bacteria, and the presence of bacterial deposits, TVC, SVC and LVC by comparison with conventional drilling methods.
The results showed that the percentage of reduction in TVC, SVC and LVC for each agent is mostly high, but not significantly different from mechanical methods. The best results were found with CCRAs when compared to polymeric drills. The results also showed that there is a lack of methodological standardization.
CCRAs have been shown to have a relevant antimicrobial effect on cariogenic bacteria; however, more studies need to be carried out using standardized methodologies.
龋齿是世界上最常见的口腔疾病。在可治疗的情况下，仍继续使用钻孔法。该技术存在缺点，因为它具有侵入性且缺乏特异性。化学机械性龋组织去除剂（CCRAs），如Carisolv™或Papacarie，是无创产品，可特异性去除感染的牙本质。另一方面，致龋细菌在很大程度上导致了病变的发生和发展。
目的是分析CCRAs对致龋细菌是否具有相关的抗菌作用。
使用PRISMA 2020在在线数据库中进行文献检索策略。通过分析致龋细菌菌落形成单位（CFUs）的减少情况，以及与传统钻孔方法相比细菌沉积物、总活菌数（TVC）、嗜中温菌数（SVC）和嗜低温菌数（LVC）的存在情况，来评估CCRAs的抗菌效果。
结果表明，每种试剂的TVC、SVC和LVC减少百分比大多较高，但与机械方法相比无显著差异。与聚合物钻头相比，CCRAs的效果最佳。结果还表明缺乏方法学标准化。
已证明CCRAs对致龋细菌具有相关的抗菌作用；然而，需要使用标准化方法进行更多研究。
