Kim Jong-Ho, Han Sung-Woo, Kwon Young-Suk, Lee Jae-June, Sohn Jong-Hee
Department of Anesthesiology and Pain Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon 24252, Republic of Korea.
Institute of New Frontier Research Team, Hallym University College of Medicine, Chuncheon 24252, Republic of Korea.
Biomedicines. 2024 Aug 2;12(8):1745. doi: 10.3390/biomedicines12081745.
Post-craniotomy headache (PCH) is a common postoperative complication, and some of these patients progress to chronic PCH (CPCH). We aimed to identify clinical variables associated with PCH and its progression to CPCH, especially possible associations between age and sex differences. Therefore, we examined clinical information on PCH using the Clinical Data Warehouse over 10 years. Of the 1326 patients included, 927 patients (69.9%) experienced PCH. In multivariate analysis for PCH, age was inversely related to risk ( = 0.003), and being female showed a significant association with an increased risk of PCH ( = 0.002). There was also a significant inverse relationship between age and severity of the worst headache, with younger female patients reporting greater severity of the worst headache ( < 0.001). Of the 927 patients who experienced PCH, 319 (34.4%) progressed to CPCH. Sex was a significant factor, with females having a higher risk of developing CPCH compared to males ( < 0.001). In addition, the presence of preoperative headaches significantly increased the risk of CPCH ( = 0.001). The occurrence of PCH is associated with younger age and female sex. In particular, female sex and preoperative headaches increased the risk of developing CPCH. These clinical factors should be considered in patients undergoing neurosurgery.
开颅术后头痛（PCH）是一种常见的术后并发症，其中一些患者会发展为慢性PCH（CPCH）。我们旨在确定与PCH及其进展为CPCH相关的临床变量，尤其是年龄和性别差异之间可能存在的关联。因此，我们使用临床数据仓库对10年间的PCH临床信息进行了研究。在纳入的1326例患者中，927例（69.9%）出现了PCH。在对PCH的多因素分析中，年龄与风险呈负相关（ = 0.003），女性与PCH风险增加显著相关（ = 0.002）。年龄与最严重头痛的严重程度之间也存在显著的负相关，年轻女性患者报告的最严重头痛的严重程度更高（ < 0.001）。在927例出现PCH的患者中，319例（34.4%）进展为CPCH。性别是一个重要因素，女性发生CPCH的风险高于男性（ < 0.001）。此外，术前头痛的存在显著增加了CPCH的风险（ = 0.001）。PCH的发生与年轻和女性性别有关。特别是，女性性别和术前头痛增加了发生CPCH的风险。在接受神经外科手术的患者中应考虑这些临床因素。
