Fernández-Martín Unai, Lisbona-González María Jesús, Vallecillo-Rivas Marta, Mallo-Magariños Manuel, Herrera-Briones Francisco Javier
Department of Oral Surgery and Implant Dentistry, School of Dentistry, Colegio Máximo de Cartuja s/n, University of Granada, 18071 Granada, Spain.
Faculty of Dentistry, Colegio Máximo de Cartuja s/n, University of Granada, 18071 Granada, Spain.
J Clin Med. 2024 Aug 7;13(16):4614. doi: 10.3390/jcm13164614.
Glucocorticoids are drugs that are increasingly used in oral surgery to reduce trismus, inflammation, and postoperative pain, three frequent complications after the surgical extraction of impacted lower third molars. The aim of this study was to compare the effect of 8 mg dexamethasone versus 40 mg methylprednisolone in the prevention of postoperative complications after third molar surgery. : A randomized double-blind clinical trial was conducted following CONSORT guidelines. In detail, 84 patients were included in the study, who randomly received a single preoperative submucosal dose of dexamethasone (8 mg) or methylprednisolone (40 mg). The variables analyzed, as primary outcomes, were trismus, inflammation, and postoperative pain. The measurements were performed at baseline (0 h), 3 h, 7 h, 24 h, 48 h, and 7 th day using a Visual Analog Scale (VAS), Verbal Rating Scale (VRS), and the Gabka-Matsumara method. : Dexamethasone reduced trismus, inflammation, and postoperative pain significantly better than methylprednisolone. : Preoperative submucosal administration of 8 mg dexamethasone is effective and safe in reducing the severity of postoperative complications following surgical extraction of impacted lower third molars.
糖皮质激素是在口腔外科手术中越来越多地用于减轻牙关紧闭、炎症和术后疼痛的药物，这些是拔除下颌阻生第三磨牙后常见的三种并发症。本研究的目的是比较8毫克地塞米松与40毫克甲泼尼龙在预防第三磨牙手术后并发症方面的效果。：按照CONSORT指南进行了一项随机双盲临床试验。具体而言，84名患者纳入研究，他们随机接受术前单次黏膜下注射地塞米松（8毫克）或甲泼尼龙（40毫克）。作为主要结局分析的变量是牙关紧闭、炎症和术后疼痛。使用视觉模拟量表（VAS）、语言评定量表（VRS）和Gabka-Matsumara方法在基线（0小时）、3小时、7小时、24小时、48小时和第7天进行测量。：地塞米松在减轻牙关紧闭、炎症和术后疼痛方面明显优于甲泼尼龙。：术前黏膜下注射8毫克地塞米松在减轻下颌阻生第三磨牙拔除术后并发症的严重程度方面是有效且安全的。
