Untaaveesup Suvijak, Kantagowit Piyawat, Leelakanok Nattawut, Chansate Petcharpa, Eiumtrakul Wongsathorn, Pratchyapruit Walaiorn, Sriphrapradang Chutintorn
Phaholpolpayuhasena Hospital, Kanchanaburi 71000, Thailand.
Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
J Clin Med. 2024 Aug 9;13(16):4668. doi: 10.3390/jcm13164668.
: Lichen sclerosus is a chronic inflammatory skin disease that affects people of all ages and sexes. Evidence of cardiovascular risk factors in lichen sclerosus has been continuously reported; however, the definitive association remains inconclusive. This meta-analysis aimed to summarize the association between cardiovascular risk factors and lichen sclerosus. : Electronic databases, including MEDLINE and EMBASE, were systematically searched from inception to May 2024 to identify the literature reporting the association between cardiovascular risk factors and lichen sclerosus. A random-effects model was used for the meta-analysis. : We included 16 eligible studies: nine case-control studies, six retrospective cohort studies, and one cross-sectional study. A total of 432,457 participants were included. Lichen sclerosus was significantly associated with type 2 diabetes mellitus with an odds ratio of 2.07 (95% CI: 1.21-3.52). Although not statistically significant, a trend of increasing risk in hypertension, dyslipidemia, obesity, and metabolic syndrome was observed among lichen sclerosus patients, with odds ratios of 1.56 (95% CI: 0.90-2.70), 1.44 (95% CI: 0.94-2.23), 5.84 (95% CI: 0.37-92.27), and 1.36 (95% CI: 0.52-3.54), respectively. : Lichen sclerosus was associated with diabetes mellitus and potentially correlated with hypertension, dyslipidemia, obesity, and metabolic syndrome. Population-based prospective observational studies are required to further elucidate these findings and assess the impact of these associations.
硬化性苔藓是一种影响所有年龄和性别的慢性炎症性皮肤病。关于硬化性苔藓中心血管危险因素的证据不断被报道；然而，确切的关联仍无定论。这项荟萃分析旨在总结心血管危险因素与硬化性苔藓之间的关联。：从数据库建立至2024年5月，系统检索了包括MEDLINE和EMBASE在内的电子数据库，以识别报道心血管危险因素与硬化性苔藓之间关联的文献。荟萃分析采用随机效应模型。：我们纳入了16项符合条件的研究：9项病例对照研究、6项回顾性队列研究和1项横断面研究。共纳入432,457名参与者。硬化性苔藓与2型糖尿病显著相关，比值比为2.07（95%置信区间：1.21 - 3.52）。虽然无统计学意义，但在硬化性苔藓患者中观察到高血压、血脂异常、肥胖和代谢综合征风险增加的趋势，比值比分别为1.56（95%置信区间：0.90 - 2.70）、1.44（95%置信区间：0.94 - 2.23）、5.84（95%置信区间：0.37 - 92.27）和1.36（95%置信区间：0.52 - 3.54）。：硬化性苔藓与糖尿病相关，并可能与高血压血脂异常、肥胖和代谢综合征相关。需要基于人群的前瞻性观察性研究来进一步阐明这些发现并评估这些关联的影响。
