Diamond M P, Wentz A C, Vaughn W K, Webster B W, Herbert C M, Osteen K G, Maxson W S
Fertil Steril. 1985 Mar;43(3):369-72. doi: 10.1016/s0015-0282(16)48433-5.
Because of the failure to conceive after the first cycle of in vitro fertilization (IVF), many couples often undergo repeated attempts. However, choosing the best stimulation protocol in successive cycles of IVF in the same individual is hindered by the lack of information regarding outcome in successive cycles following utilization of the same or different stimulation protocols. Examination of repeated cycles of the same stimulation protocol in 33 women demonstrated that comparing women with an initial "A" estradiol (E2) pattern (daily E2 levels that continued to rise throughout the stimulation) and those with non-A E2 patterns (failure to have continually rising E2 levels throughout the stimulation), the former were significantly less likely to have a subsequent passed cycle (P = 0.007) and tended to be more likely to have a subsequent A cycle (P = 0.079). Changing the stimulation protocol resulted in a different E2 pattern in 15 of 20 subsequent cycles. Thus, it is suggested that after a cycle with an acceptable E2 pattern, successive cycles be performed with the same stimulation protocol. However, after an initial unacceptable E2 pattern, it may be more efficacious to utilize an alternate stimulation protocol.
由于在第一个体外受精（IVF）周期后未能受孕，许多夫妇常常会进行反复尝试。然而，由于缺乏关于使用相同或不同刺激方案后的连续周期结果的信息，在同一个体的连续IVF周期中选择最佳刺激方案受到了阻碍。对33名女性的相同刺激方案的重复周期进行检查发现，将具有初始“A”雌二醇（E2）模式（在整个刺激过程中每日E2水平持续上升）的女性与具有非“A”E2模式（在整个刺激过程中E2水平未能持续上升）的女性进行比较，前者后续周期成功的可能性显著更低（P = 0.007），且更倾向于后续出现“A”周期（P = 0.079）。在20个后续周期中的15个周期里，改变刺激方案导致了不同的E2模式。因此，建议在一个具有可接受的E2模式的周期后，后续周期采用相同的刺激方案。然而，在初始E2模式不可接受之后，采用另一种刺激方案可能更有效。
