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The prevalence of endometriosis in unexplained infertility: a systematic review.不明原因不孕中子宫内膜异位症的患病率:系统评价。
Reprod Biomed Online. 2024 Sep;49(3):103848. doi: 10.1016/j.rbmo.2024.103848. Epub 2024 Feb 2.
2
Beyond the surface: Does stage I-II endometriosis impact fertility? Exploring the challenges of mild disease.深入探讨:I 期-II 期子宫内膜异位症是否影响生育能力?探究轻度疾病带来的挑战。
Best Pract Res Clin Obstet Gynaecol. 2024 Sep;96:102501. doi: 10.1016/j.bpobgyn.2024.102501. Epub 2024 May 9.
3
Saliva-based microRNA diagnostic signature for the superficial peritoneal endometriosis phenotype.基于唾液的微小 RNA 诊断特征用于表浅腹膜子宫内膜异位症表型。
Eur J Obstet Gynecol Reprod Biol. 2024 Jun;297:187-196. doi: 10.1016/j.ejogrb.2024.04.020. Epub 2024 Apr 17.
4
The Visual Effect of a Down-Regulation With Dienogest and GnRH Analogues in Endometriosis: Lessons Learned From Two-Step Surgical Approach.地诺孕素与 GnRH 类似物下调治疗子宫内膜异位症的视觉效果:两步手术方法的经验教训。
J Minim Invasive Gynecol. 2024 May;31(5):369-370. doi: 10.1016/j.jmig.2024.02.003. Epub 2024 Feb 12.
5
Impact of Endometriosis Surgery on In Vitro Fertilization/Intracytoplasmic Sperm Injection Outcomes: a Systematic Review and Meta-analysis.子宫内膜异位症手术对体外受精/卵胞浆内单精子注射结局的影响:一项系统评价和Meta分析
Reprod Sci. 2024 Jun;31(6):1431-1455. doi: 10.1007/s43032-023-01421-7. Epub 2024 Jan 2.
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Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility.氧化应激作为潜在的轻微和轻度子宫内膜异位症相关不孕的潜在原因。
Int J Mol Sci. 2023 Feb 14;24(4):3809. doi: 10.3390/ijms24043809.
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Oxidative stress-related effects on various aspects of endometriosis.氧化应激对子宫内膜异位症各个方面的影响。
Am J Reprod Immunol. 2022 Sep;88(3):e13593. doi: 10.1111/aji.13593. Epub 2022 Jul 10.
8
Existence of chronic endometritis and its influence on pregnancy outcomes in infertile women with minimal/mild endometriosis.慢性子宫内膜炎的存在及其对轻度/中度子宫内膜异位症不孕女性妊娠结局的影响。
Int J Gynaecol Obstet. 2023 Feb;160(2):628-634. doi: 10.1002/ijgo.14326. Epub 2022 Jul 15.
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Effectiveness of gonadotrophin-releasing hormone agonist therapy to improve the outcomes of intrauterine insemination in patients suffering from stage I-II endometriosis.促性腺激素释放激素激动剂治疗对改善Ⅰ-Ⅱ期子宫内膜异位症患者宫腔内人工授精结局的有效性。
Ann Med. 2022 Dec;54(1):1330-1338. doi: 10.1080/07853890.2022.2071458.
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ESHRE guideline: endometriosis.ESHRE 指南:子宫内膜异位症。
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腹腔镜手术对轻度/中度子宫内膜异位症患者生育结局的影响。

The Impact of Laparoscopic Surgery on Fertility Outcomes in Patients with Minimal/Mild Endometriosis.

作者信息

Grigoriadis Georgios, Roman Horace, Gkrozou Fani, Daniilidis Angelos

机构信息

1st University Department in Obstetrics and Gynecology, Papageorgiou General Hospital, School of Medicine, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece.

Institut Franco-Europeen Multidisciplinaire d'Endometriose (IFEMEndo), Endometriosis Centre, CliniqueTivoli-Ducos, 33000 Bordeaux, France.

出版信息

J Clin Med. 2024 Aug 15;13(16):4817. doi: 10.3390/jcm13164817.

DOI:10.3390/jcm13164817
PMID:39200960
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11355624/
Abstract

Minimal/mild endometriosis (MME) is independently associated with reduced fecundity rates. In this review article, we discuss the role of laparoscopic surgery in enhancing the fertility outcomes of patients with MME. Laparoscopic management of MME enhances fecundity and increases the chances of spontaneous conception in appropriately selected cases. However, laparoscopy cannot be routinely recommended in asymptomatic patients with the sole purpose of diagnosing and treating potentially present MME. Equally, and based on existing information, the laparoscopic management of MME cannot be routinely recommended prior to in vitro fertilisation (IVF) attempts due to the lack of robust and beneficial evidence. Because an overlap between unexplained infertility and MME cases likely exists, the development of reliable, widely available, non-invasive tests for the diagnosis of MME may revolutionise the management of cases currently classified as unexplained infertility. In a disease as diverse as endometriosis, management decisions should be based on a multitude of factors. Future studies should focus on reporting the outcomes of interventions for MME on fertility and obstetric outcomes, clearly differentiating between disease stages and phenotypes.

摘要

轻度/微小子宫内膜异位症(MME)与生育力降低独立相关。在这篇综述文章中,我们讨论了腹腔镜手术在改善MME患者生育结局方面的作用。MME的腹腔镜治疗可提高生育力,并在适当选择的病例中增加自然受孕的机会。然而,对于无症状患者,不能仅为了诊断和治疗潜在存在的MME而常规推荐腹腔镜检查。同样,根据现有信息,由于缺乏有力且有益的证据,在尝试体外受精(IVF)之前,不能常规推荐对MME进行腹腔镜治疗。由于不明原因不孕症与MME病例之间可能存在重叠,开发可靠、广泛可用的非侵入性MME诊断测试可能会彻底改变目前归类为不明原因不孕症的病例管理。在像子宫内膜异位症这样复杂多样的疾病中,管理决策应基于多种因素。未来的研究应侧重于报告MME干预措施对生育和产科结局的影响,明确区分疾病阶段和表型。