Grigoriadis Georgios, Roman Horace, Gkrozou Fani, Daniilidis Angelos
1st University Department in Obstetrics and Gynecology, Papageorgiou General Hospital, School of Medicine, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece.
Institut Franco-Europeen Multidisciplinaire d'Endometriose (IFEMEndo), Endometriosis Centre, CliniqueTivoli-Ducos, 33000 Bordeaux, France.
J Clin Med. 2024 Aug 15;13(16):4817. doi: 10.3390/jcm13164817.
Minimal/mild endometriosis (MME) is independently associated with reduced fecundity rates. In this review article, we discuss the role of laparoscopic surgery in enhancing the fertility outcomes of patients with MME. Laparoscopic management of MME enhances fecundity and increases the chances of spontaneous conception in appropriately selected cases. However, laparoscopy cannot be routinely recommended in asymptomatic patients with the sole purpose of diagnosing and treating potentially present MME. Equally, and based on existing information, the laparoscopic management of MME cannot be routinely recommended prior to in vitro fertilisation (IVF) attempts due to the lack of robust and beneficial evidence. Because an overlap between unexplained infertility and MME cases likely exists, the development of reliable, widely available, non-invasive tests for the diagnosis of MME may revolutionise the management of cases currently classified as unexplained infertility. In a disease as diverse as endometriosis, management decisions should be based on a multitude of factors. Future studies should focus on reporting the outcomes of interventions for MME on fertility and obstetric outcomes, clearly differentiating between disease stages and phenotypes.
轻度/微小子宫内膜异位症(MME)与生育力降低独立相关。在这篇综述文章中,我们讨论了腹腔镜手术在改善MME患者生育结局方面的作用。MME的腹腔镜治疗可提高生育力,并在适当选择的病例中增加自然受孕的机会。然而,对于无症状患者,不能仅为了诊断和治疗潜在存在的MME而常规推荐腹腔镜检查。同样,根据现有信息,由于缺乏有力且有益的证据,在尝试体外受精(IVF)之前,不能常规推荐对MME进行腹腔镜治疗。由于不明原因不孕症与MME病例之间可能存在重叠,开发可靠、广泛可用的非侵入性MME诊断测试可能会彻底改变目前归类为不明原因不孕症的病例管理。在像子宫内膜异位症这样复杂多样的疾病中,管理决策应基于多种因素。未来的研究应侧重于报告MME干预措施对生育和产科结局的影响,明确区分疾病阶段和表型。