Chihara Etsuo, Hamanaka Teruhiko
Sensho-Kai Eye Institute, Minamiyama 50-1, Iseda, Kyoto 611-0043, Japan.
Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo 150-8935, Japan.
J Clin Med. 2024 Aug 19;13(16):4882. doi: 10.3390/jcm13164882.
Glaucoma is one of the primary causes of blindness worldwide. Canal opening surgery, a type of minimally invasive glaucoma surgery (MIGS) applied in cases of mild to moderate glaucoma, has gained increasing popularity in recent years due to its efficacy in reducing the intraocular pressure, its safety profile, the simplicity of its technique, and the reduced likelihood of compromised vision. Nevertheless, the existing body of histopathological studies remains insufficient for a comprehensive understanding of post-surgical wound healing. Consequently, debates persist among researchers regarding the mechanism through which Schlemm's canal opening surgery reduces the intraocular pressure, as well as the surgical techniques that may impact the outcomes and the factors influencing surgical success. As the history of MIGS is relatively short and lacks sufficient systemic reviews or meta-analyses evaluating the influence of individual factors, this review was conducted to illuminate the disparities in researchers' opinions at the current stage of research.
青光眼是全球失明的主要原因之一。房角开放手术是一种应用于轻至中度青光眼病例的微创青光眼手术（MIGS），近年来因其在降低眼压方面的疗效、安全性、技术的简单性以及视力受损可能性降低而越来越受欢迎。然而，现有的组织病理学研究仍不足以全面了解术后伤口愈合情况。因此，研究人员对于施莱姆管开放手术降低眼压的机制、可能影响手术效果的手术技术以及影响手术成功的因素仍存在争议。由于MIGS的历史相对较短，缺乏足够的系统评价或荟萃分析来评估个体因素的影响，因此进行本综述以阐明研究现阶段研究人员观点的差异。
