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阿位伯人群中曲马多使用的遗传药理学方法。

Pharmacogenetic Approach to Tramadol Use in the Arab Population.

机构信息

Seoul Shingil Rehabilitation Medicine Clinic, 162 Shingil-ro, Yeongdeungpo-gu, Seoul 07362, Republic of Korea.

Jeju Research Institute of Pharmaceutical Sciences, College of Pharmacy, Jeju National University, 102 Jejudaehak-ro, Jeju-si 63243, Jeju-do, Republic of Korea.

出版信息

Int J Mol Sci. 2024 Aug 16;25(16):8939. doi: 10.3390/ijms25168939.

DOI:10.3390/ijms25168939
PMID:39201627
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11354576/
Abstract

Tramdol is one of most popular opioids used for postoperative analgesia worldwide. Among Arabic countries, there are reports that its dosage is not appropriate due to cultural background. To provide theoretical background of the proper usage of tramadol, this study analyzed the association between several genetic polymorphisms (CYP2D6/OPRM1) and the effect of tramadol. A total of 39 patients who took tramadol for postoperative analgesia were recruited, samples were obtained, and their DNA was extracted for polymerase chain reaction products analysis followed by allelic variations of CYP2D6 and OPRM A118G determination. Numerical pain scales were measured before and 1 h after taking tramadol. The effect of tramadol was defined by the difference between these scales. We concluded that CYP2D6 and OPRM1 A118G single nucleotide polymorphisms may serve as crucial determinants in predicting tramadol efficacy and susceptibility to post-surgical pain. Further validation of personalized prescription practices based on these genetic polymorphisms could provide valuable insights for the development of clinical guidelines tailored to post-surgical tramadol use in the Arabic population.

摘要

曲马多是全球范围内最常用的阿片类药物之一，用于术后镇痛。在阿拉伯国家，有报道称由于文化背景的原因，其剂量并不合适。为了提供曲马多合理使用的理论基础，本研究分析了几种遗传多态性（CYP2D6/OPRM1）与曲马多效应之间的关系。共招募了 39 名接受曲马多术后镇痛的患者，采集样本并提取 DNA，进行聚合酶链反应产物分析，确定 CYP2D6 和 OPRM1 A118G 的等位基因变异。在服用曲马多前和 1 小时后测量数字疼痛量表，以曲马多的差值来定义其效果。我们得出结论，CYP2D6 和 OPRM1 A118G 单核苷酸多态性可能是预测曲马多疗效和对术后疼痛易感性的关键决定因素。基于这些遗传多态性的个体化处方实践的进一步验证，可能为制定针对阿拉伯人群术后使用曲马多的临床指南提供有价值的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c150/11354576/a461251b4d72/ijms-25-08939-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c150/11354576/ec53e242570c/ijms-25-08939-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c150/11354576/5984e1560b5f/ijms-25-08939-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c150/11354576/f9eb9039a98a/ijms-25-08939-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c150/11354576/a461251b4d72/ijms-25-08939-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c150/11354576/ec53e242570c/ijms-25-08939-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c150/11354576/5984e1560b5f/ijms-25-08939-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c150/11354576/f9eb9039a98a/ijms-25-08939-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c150/11354576/a461251b4d72/ijms-25-08939-g004.jpg

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