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不同分级前列腺癌发病机制中的前列腺组织微生物组。

Different Prostatic Tissue Microbiomes between High- and Low-Grade Prostate Cancer Pathogenesis.

机构信息

Department of Urology, Soonchunhyang University School of Medicine, Seoul 04401, Republic of Korea.

Department of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Asan 31151, Republic of Korea.

出版信息

Int J Mol Sci. 2024 Aug 16;25(16):8943. doi: 10.3390/ijms25168943.

DOI:10.3390/ijms25168943
PMID:39201629
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11354394/
Abstract

Numerous human pathologies, such as neoplasia, are related to particular bacteria and changes in microbiome constituents. To investigate the association between an imbalance of bacteria and prostate carcinoma, the microbiome and gene functionality from tissues of patients with high-grade prostate tumor (HGT) and low-grade prostate tumor (LGT) were compared utilizing next-generation sequencing (NGS) technology. The results showed abnormalities in the bacterial profiles between the HGT and LGT specimens, indicating alterations in the make-up of bacterial populations and gene functionalities. The HGT specimens showed higher frequencies of , , and genera than the LGT specimens. Cell proliferation and cytokine assays also showed a significant proliferation of prostate cancer cells and elevated cytokine levels in the cells treated with , respectively, supporting earlier findings. In summary, the HGT and LGT specimens showed differences in bacterial populations, suggesting that different bacterial populations might characterize high-grade and low-grade prostate malignancies.

摘要

许多人类病理学疾病，如肿瘤，都与特定的细菌和微生物群组成的变化有关。为了研究细菌失衡与前列腺癌之间的关系，利用下一代测序（NGS）技术比较了高分级前列腺肿瘤（HGT）和低分级前列腺肿瘤（LGT）患者组织的微生物组和基因功能。结果表明，HGT 和 LGT 标本之间的细菌谱存在异常，表明细菌种群和基因功能的组成发生了改变。HGT 标本中 、 、 和 属的出现频率高于 LGT 标本。细胞增殖和细胞因子测定也表明，用 处理的前列腺癌细胞增殖显著，细胞因子水平升高，这与早期的研究结果一致。总之，HGT 和 LGT 标本的细菌种群存在差异，表明不同的细菌种群可能是高分级和低分级前列腺恶性肿瘤的特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd55/11354394/5362c7343fd2/ijms-25-08943-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd55/11354394/0f3375183d45/ijms-25-08943-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd55/11354394/0678d518bdfa/ijms-25-08943-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd55/11354394/ed0bf3ac3e7d/ijms-25-08943-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd55/11354394/81202fbb9728/ijms-25-08943-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd55/11354394/73fb64ab8e0b/ijms-25-08943-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd55/11354394/fb26735015fa/ijms-25-08943-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd55/11354394/25ce1bc490cc/ijms-25-08943-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd55/11354394/9bccc7631f95/ijms-25-08943-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd55/11354394/5362c7343fd2/ijms-25-08943-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd55/11354394/0f3375183d45/ijms-25-08943-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd55/11354394/0678d518bdfa/ijms-25-08943-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd55/11354394/ed0bf3ac3e7d/ijms-25-08943-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd55/11354394/81202fbb9728/ijms-25-08943-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd55/11354394/73fb64ab8e0b/ijms-25-08943-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd55/11354394/fb26735015fa/ijms-25-08943-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd55/11354394/25ce1bc490cc/ijms-25-08943-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd55/11354394/9bccc7631f95/ijms-25-08943-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd55/11354394/5362c7343fd2/ijms-25-08943-g009.jpg

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Different Prostatic Tissue Microbiomes between High- and Low-Grade Prostate Cancer Pathogenesis.

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引用本文的文献

[1]
Association of Intratumoral Microbiota Modulation with Prostate Cancer Progression: A Microbiome Analysis of Prostatic Tissue.

Biomedicines. 2025-8-7

[2]
Prostate and urinary microbiomes in prostate cancer development: focus on .

Front Cell Infect Microbiol. 2025-5-21

[3]
Microbiome in urologic neoplasms: focusing on tumor immunity.

Front Immunol. 2024-12-5

本文引用的文献

[1]
Cutibacterium acnes invades prostate epithelial cells to induce BRCAness as a possible pathogen of prostate cancer.

Prostate. 2024-8

[2]
Cutibacterium acnes-derived extracellular vesicles promote tumor growth in renal cell carcinoma.

Cancer Sci. 2024-8

[3]
Social and psychological adversity are associated with distinct mother and infant gut microbiome variations.

Nat Commun. 2023-9-20

[4]
Biochemical Recurrence in Prostate Cancer Is Associated with the Composition of : Microbiome Analysis of Prostatic Tissue.

Int J Mol Sci. 2023-6-21

[5]
Longevity of centenarians is reflected by the gut microbiome with youth-associated signatures.

Nat Aging. 2023-4

[6]
Microbiota of Urine, Glans and Prostate Biopsies in Patients with Prostate Cancer Reveals a Dysbiosis in the Genitourinary System.

Cancers (Basel). 2023-2-23

[7]
Immunological analysis of Interleukin-10 (IL-10), tumor necrosis factor-a (TNF-a), and Prostate-specific antigen (PSA) in benign and malignant prostate cancer.

Hum Antibodies. 2023-1-18

[8]
Microbiome and Prostate Cancer: A Novel Target for Prevention and Treatment.

Int J Mol Sci. 2023-1-12

[9]
Malignant Prostate Tissue Is Associated with Different Microbiome Gene Functions.

Diagnostics (Basel). 2023-1-11

[10]
Role of microbiome and its metabolite, short chain fatty acid in prostate cancer.

Investig Clin Urol. 2023-1

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