Kim Jae Heon, Seo Hoonhee, Kim Sukyung, Rahim Md Abdur, Jo Sujin, Barman Indrajeet, Tajdozian Hanieh, Sarafraz Faezeh, Shuvo Md Sarower Hossen, Song Ho-Yeon, Song Yun Seob
Department of Urology, School of Medicine, Soonchunhyang University, Seoul 14584, Republic of Korea.
Human Microbiome Medical Research Center (HM∙MRC), School of Medicine, Soonchunhyang University, Chungnam 31538, Republic of Korea.
Biomedicines. 2025 Aug 7;13(8):1929. doi: 10.3390/biomedicines13081929.
The involvement of the intratumoral microbiome in prostate cancer progression is becoming increasingly acknowledged. This study analyzed the microbiome of prostate cancer tissues from patients with localized prostate cancer (LPC, stages 1-2) and advanced prostate cancer (APC, stages 3-4) to determine its association with cancer progression. Paraffin-embedded tissue samples obtained during radical prostatectomy underwent 16S rRNA amplicon-based profiling. The profile of the bacterial communities in LPC and APC differed remarkably. While species diversity remained stable, species richness (as determined by the ACE analysis) was significantly lower in APC, correlating with a decrease in (which is more abundant in LPC) and an increase in (enriched in APC). The role of in the progression of cancer was confirmed by in vitro studies employing cell lines from prostate cancer. These findings demonstrate the potential of microbiome-targeted interventions in the management of prostate cancer.
肿瘤内微生物群在前列腺癌进展中的作用越来越受到认可。本研究分析了局限性前列腺癌（LPC，1-2期）和晚期前列腺癌（APC，3-4期）患者前列腺癌组织的微生物群，以确定其与癌症进展的关联。在根治性前列腺切除术中获得的石蜡包埋组织样本进行了基于16S rRNA扩增子的分析。LPC和APC中细菌群落的特征有显著差异。虽然物种多样性保持稳定，但APC中的物种丰富度（由ACE分析确定）显著较低，这与LPC中丰度更高的 减少以及APC中富集的 增加相关。通过使用前列腺癌细胞系的体外研究证实了 在癌症进展中的作用。这些发现证明了针对微生物群的干预措施在前列腺癌管理中的潜力。
