基于大环的超分子药物传递系统：简要综述。

Macrocycle-Based Supramolecular Drug Delivery Systems: A Concise Review.

机构信息

College of Pharmacy, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai Tibet Plateau, Southwest Minzu University, Chengdu 610041, China.

College of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu 610041, China.

出版信息

Molecules. 2024 Aug 12;29(16):3828. doi: 10.3390/molecules29163828.

DOI:10.3390/molecules29163828

PMID:39202907

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11357536/

Abstract

Efficient delivery of therapeutic agents to the lesion site or specific cells is an important way to achieve "toxicity reduction and efficacy enhancement". Macrocycles have always provided many novel ideas for drug or gene loading and delivery processes. Specifically, macrocycles represented by crown ethers, cyclodextrins, cucurbit[n]urils, calix[n]arenes, and pillar[n]arenes have unique properties, which are different cavity structures, good biocompatibility, and good stability. Benefited from these diverse properties, a variety of supramolecular drug delivery systems can be designed and constructed to effectively improve the physical and chemical properties of guest molecules as needed. This review provides an outlook on the current application status and main limitations of macrocycles in supramolecular drug delivery systems.

摘要

高效地将治疗剂递送到病变部位或特定细胞是实现“降低毒性和提高疗效”的重要途径。大环化合物一直为药物或基因负载和递药过程提供了许多新颖的思路。具体来说，冠醚、环糊精、瓜环、杯芳烃和柱芳烃等以大环为代表的化合物具有独特的性质，如不同的空腔结构、良好的生物相容性和稳定性。得益于这些多样化的性质，可以设计和构建各种超分子药物传递系统，以有效地根据需要改善客体分子的物理和化学性质。本文综述了大环在超分子药物传递系统中的应用现状和主要局限性。