Department of Chemistry, University of Fort Hare, Alice Campus, Alice 5700, Eastern Cape, South Africa.
Molecules. 2024 Aug 16;29(16):3884. doi: 10.3390/molecules29163884.
Ursolic acid (UA) and its derivatives have garnered significant attention due to their extensive pharmacological activity. UA is a pentacyclic triterpenoid found in a variety of plants, such as apples, rosemary, thyme, etc., and it possesses a range of pharmacological properties. Researchers have synthesized various derivatives of UA through structural modifications to enhance its potential pharmacological properties. Various in vitro and in vivo studies have indicated that UA and its derivatives possess diverse biological activities, such as anticancer, antifungal, antidiabetic, antioxidant, antibacterial, anti-inflammatory and antiviral properties. This review article provides a review of the biological activities of UA and its derivatives to show their valuable therapeutic properties useful in the treatment of different diseases, mainly focusing on the relevant structure-activity relationships (SARs), the underlying molecular targets/pathways, and modes of action.
熊果酸（UA）及其衍生物因其广泛的药理学活性而备受关注。UA 是一种五环三萜类化合物，存在于多种植物中，如苹果、迷迭香、百里香等，具有多种药理学特性。研究人员通过结构修饰合成了各种 UA 衍生物，以增强其潜在的药理学特性。各种体外和体内研究表明，UA 及其衍生物具有多种生物活性，如抗癌、抗真菌、抗糖尿病、抗氧化、抗菌、抗炎和抗病毒活性。本文综述了 UA 及其衍生物的生物学活性，以展示其在治疗不同疾病方面的有价值的治疗特性，主要集中在相关的构效关系（SAR）、潜在的分子靶点/途径和作用模式上。
