青蒿素及其衍生物作为潜在的抗癌药物。

Institute of Chinese Medicine and State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, The Chinese University of Hong Kong, Hong Kong, China.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.

Molecules. 2024 Aug 16;29(16):3886. doi: 10.3390/molecules29163886.

Artemisinin is a natural sesquiterpene lactone obtained from the traditional Chinese medicinal herb L. (). Artemisinin and its derivatives share an unusual endoperoxide bridge and are extensively used for malaria treatment worldwide. In addition to antimalarial activities, artemisinin and its derivatives have been reported to exhibit promising anticancer effects in recent decades. In this review, we focused on the research progress of artemisinin and its derivatives with potential anticancer activities. The pharmacological effects, potential mechanisms, and clinical trials in cancer therapy of artemisinin and its derivatives were discussed. This review may facilitate the future exploration of artemisinin and its derivatives as effective anticancer agents.

青蒿素是一种从传统中药黄花蒿（）中提取的天然倍半萜内酯。青蒿素及其衍生物都含有一个独特的内过氧桥，在全世界范围内被广泛用于疟疾的治疗。除了抗疟活性外，青蒿素及其衍生物在近几十年来被报道具有很有前景的抗癌作用。在这篇综述中，我们专注于具有潜在抗癌活性的青蒿素及其衍生物的研究进展。讨论了青蒿素及其衍生物的药理学作用、潜在作用机制和在癌症治疗中的临床试验。这篇综述可能有助于未来探索青蒿素及其衍生物作为有效的抗癌药物。