Lissa Sonia Maria, Lapinski Bruna Amaral, Graf Maria Ester, Reda Somaia, Debur Maria do Carmo, Presibella Mayra, Pereira Luciane Aparecida, de Carvalho Newton Sérgio, Carvalho de Oliveira Jaqueline, Raboni Sonia Mara, Nogueira Meri Bordignon
Postgraduate Program in Tocogynecology and Women's Health, Federal University of Parana Universidade Federal do Paraná, Curitiba 80060-900, Brazil.
Postgraduate Program in Internal Medicine and Health Science, Federal University of Parana, Curitiba 80060-900, Brazil.
Microorganisms. 2024 Jul 30;12(8):1555. doi: 10.3390/microorganisms12081555.
Pregnant women (PW) are at a higher risk of diseases and hospitalization from viral respiratory infections, particularly influenza and SARS-CoV-2, due to cardiopulmonary and immunological changes. This study assessed the impact of viral respiratory infections on PW hospitalized with severe acute respiratory infection (SARI) prior to the COVID-19 pandemic. It is a cross-sectional study with 42 PW and 85 non-pregnant women (NPW) admitted with SARI to two tertiary hospitals between January 2015 and December 2019. The rates of virus prevalence, SARI hospitalization, length of hospital stay, oxygen supplementation, intensive care unit (ICU) admission, and death were comparable between PW and NPW. A multivariate analysis showed that PW had a higher rate of viral SARI hospitalizations (OR = 2.37; 95% CI = 1.02-5.48) as compared to NPW, with the influenza virus being the most prevalent (aOR = 7.58; 95% CI = 1.53-37.66). The length of hospital stays (aOR = 0.83; 95% CI = 0.73-0.95) and admissions to the ICU (aOR = 0.028; 95% CI = 0.004-0.25) were lower in PW as compared to hospitalized NPW. The influenza virus had a greater impact on the frequency of SARI in the group of PW, and these had a better outcome than NPW due to the earlier antiviral treatment they received.
由于心肺和免疫方面的变化，孕妇更容易因病毒性呼吸道感染而患病并住院，尤其是流感和新冠病毒。本研究评估了病毒性呼吸道感染对在新冠疫情大流行之前因严重急性呼吸道感染（SARI）住院的孕妇的影响。这是一项横断面研究，在2015年1月至2019年12月期间，对两家三级医院收治的42名孕妇和85名非孕妇（NPW）进行了SARI评估。孕妇和非孕妇在病毒流行率、SARI住院率、住院时间、吸氧、重症监护病房（ICU）入院率和死亡率方面相当。多变量分析显示，与非孕妇相比，孕妇因病毒性SARI住院的比例更高（OR = 2.37；95% CI = 1.02 - 5.48），其中流感病毒最为常见（aOR = 7.58；95% CI = 1.53 - 37.66）。与住院的非孕妇相比，孕妇的住院时间（aOR = 0.83；95% CI = 0.73 - 0.95）和ICU入院率（aOR = 0.028；95% CI = 0.004 - 0.25）更低。流感病毒对孕妇组SARI的发生频率影响更大，并且由于她们接受了更早的抗病毒治疗，其预后比非孕妇更好。
