Park Daerl, Jeong Hyeonyeong, Choi Jungsik, Han Juyeon, Piao Honglin, Kim Jaehyun, Park Seonghoon, Song Mingu, Kim Dowoo, Sung Jaesuk, Cheong Eunji, Choi Heonjin
Department of Materials Science and Engineering, Yonsei University, Seoul 03722, Republic of Korea.
Department of Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.
Micromachines (Basel). 2024 Aug 22;15(8):1058. doi: 10.3390/mi15081058.
Monitoring neural activity in the central nervous system often utilizes silicon-based microelectromechanical system (MEMS) probes. Despite their effectiveness in monitoring, these probes have a fragility issue, limiting their application across various fields. This study introduces flexible printed circuit board (FPCB) neural probes characterized by robust mechanical and electrical properties. The probes demonstrate low impedance after platinum coating, making them suitable for multiunit recordings in awake animals. This capability allows for the simultaneous monitoring of a large population of neurons in the brain, including cluster data. Additionally, these probes exhibit no fractures, mechanical failures, or electrical issues during repeated-bending tests, both during handling and monitoring. Despite the possibility of using this neural probe for signal measurement in awake animals, simply applying a platinum coating may encounter difficulties in chronic tests and other applications. Furthermore, this suggests that FPCB probes can be advanced by any method and serve as an appropriate type of tailorable neural probes for monitoring neural systems in awake animals.
监测中枢神经系统中的神经活动通常使用基于硅的微机电系统（MEMS）探针。尽管这些探针在监测方面很有效，但它们存在易碎性问题，限制了它们在各个领域的应用。本研究介绍了具有强大机械和电气性能的柔性印刷电路板（FPCB）神经探针。这些探针在镀铂后显示出低阻抗，使其适用于清醒动物的多单元记录。这种能力允许同时监测大脑中的大量神经元，包括集群数据。此外，这些探针在处理和监测过程中的反复弯曲测试中均未出现断裂、机械故障或电气问题。尽管有可能将这种神经探针用于清醒动物的信号测量，但仅应用铂涂层在慢性测试和其他应用中可能会遇到困难。此外，这表明FPCB探针可以通过任何方法进行改进，并作为一种合适的可定制神经探针用于监测清醒动物的神经系统。
