成年乳糜泻患者坚持无麸质饮食的韧性：一项意大利多中心横断面研究。

Resilience in Adult Coeliac Patients on a Gluten-Free Diet: A Cross-Sectional Multicentre Italian Study.

机构信息

Department of Internal Medicine and Therapeutics, University of Pavia, Italy, 27100 Pavia, Italy.

Gastroenterology Unit of Pavia Institute, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.

出版信息

Nutrients. 2024 Aug 7;16(16):2595. doi: 10.3390/nu16162595.

DOI:10.3390/nu16162595

PMID:39203732

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11357567/

Abstract

BACKGROUND

Data on resilience, the ability to recover from adversity, in coeliac disease (CeD) are lacking.

AIM

To assess the degree of resilience in patients with CeD on a gluten-free diet (GFD), and its association with clinical features, sociodemographic factors, psychological morbidity, and quality of life (QOL).

METHODS

A cross-sectional multicentre Italian study was conducted on adult CeD patients between May 2022 and April 2023. Connor-Davidson Resilience Scale (CD-RISC), the Coeliac Disease-specific Quality of Life Scale (CD-QOL), the State-Trait Anxiety Inventory scale (STAI-Y), and the Beck Depression Inventory scale (BDI) were used to evaluate resilience, QOL, anxiety, and depression, respectively. A multivariate analysis was conducted to identify factors independently associated with the degree of resilience.

RESULTS

A total of 305 patients (221 F, mean age at CeD diagnosis 36 ± 16 years) on a long-term GFD (median 8 years, IQR 3-17) were enrolled. A total of 298/305 patients (98%) had a high level of resilience (CD-RISC ≥ 35). At univariate analysis, resilience was statistically associated with male gender ( = 0.03), age at enrolment ( = 0.02), marital status ( = 0.03), QOL ( < 0.001), anxiety ( < 0.001), and depression ( < 0.001). On multivariate regression analysis, trait anxiety (STAI-Y2, < 0.001) and depression (BDI, = 0.02) were independent predictors of lower levels of resilience.

CONCLUSIONS

Higher trait anxiety predicts lower levels of resilience. Targeted interventions in this subgroup of patients may be helpful for their management and follow-up.

摘要

背景

关于韧性的研究，即从逆境中恢复的能力，在乳糜泻（CeD）中较为缺乏。

目的

评估接受无麸质饮食（GFD）的 CeD 患者的韧性程度，并评估其与临床特征、社会人口学因素、心理困扰和生活质量（QOL）的关系。

方法

本研究为意大利的一项横断面多中心研究，于 2022 年 5 月至 2023 年 4 月间招募成年 CeD 患者。使用 Connor-Davidson 韧性量表（CD-RISC）、乳糜泻特异性生活质量量表（CD-QOL）、状态特质焦虑量表（STAI-Y）和贝克抑郁量表（BDI）分别评估韧性、QOL、焦虑和抑郁。采用多变量分析确定与韧性程度相关的独立因素。

结果

共纳入 305 名长期接受 GFD（中位数 8 年，IQR 3-17 年）的患者（221 名女性，CeD 诊断时的平均年龄为 36 ± 16 岁）。298/305 名患者（98%）的韧性程度较高（CD-RISC≥35）。单因素分析显示，韧性程度与男性（ = 0.03）、入组时的年龄（ = 0.02）、婚姻状况（ = 0.03）、QOL（ < 0.001）、焦虑（ < 0.001）和抑郁（ < 0.001）有关。多变量回归分析显示，特质焦虑（STAI-Y2， < 0.001）和抑郁（BDI， = 0.02）是韧性程度较低的独立预测因素。