Yount Kacy S, Darville Toni
Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Vaccines (Basel). 2024 Aug 1;12(8):863. doi: 10.3390/vaccines12080863.
Sexually transmitted infections (STIs) caused by bacterial pathogens , , and present significant public health challenges. These infections profoundly impact reproductive health, leading to pelvic inflammatory disease, infertility, and increased susceptibility to other infections. Prevention measures, including antibiotic treatments, are limited by the often-asymptomatic nature of these infections, the need for repetitive and continual screening of sexually active persons, antibiotic resistance for gonorrhea, and shortages of penicillin for syphilis. While vaccines exist for viral STIs like human papillomavirus (HPV) and hepatitis B virus (HBV), there are no vaccines available for bacterial STIs. This review examines the immune responses in the female genital tract to these bacterial pathogens and the implications for developing effective vaccines against bacterial STIs.
由细菌病原体[具体病原体未给出]引起的性传播感染（STIs）带来了重大的公共卫生挑战。这些感染对生殖健康产生深远影响，可导致盆腔炎、不孕不育，并增加对其他感染的易感性。预防措施，包括抗生素治疗，受到这些感染通常无症状的特性、对性活跃人群进行重复和持续筛查的必要性、淋病的抗生素耐药性以及梅毒治疗用青霉素短缺的限制。虽然存在针对人乳头瘤病毒（HPV）和乙型肝炎病毒（HBV）等病毒性性传播感染的疫苗，但尚无针对细菌性性传播感染的疫苗。本综述研究了女性生殖道对这些细菌病原体的免疫反应以及对开发针对细菌性性传播感染的有效疫苗的意义。
