基于病毒载体的结核病疫苗研究趋势:专利综述(2010 - 2023年)
Trends in Viral Vector-Based Vaccines for Tuberculosis: A Patent Review (2010-2023).
作者信息
Santos Lana C, Fernandes Antônio Márcio Santana, Alves Izabel Almeida, Serafini Mairim Russo, Silva Leandra da Silva E, de Freitas Humberto Fonseca, Leite Luciana C C, Santos Carina C
机构信息
Serviço de Imunologia das Doenças Infecciosas, Faculdade de Farmácia, Universidade Federal da Bahia, Salvador 40170-115, BA, Brazil.
Departamento do Medicamento, Faculdade de Farmácia, Universidade Federal da Bahia, Salvador 40170-115, BA, Brazil.
出版信息
Vaccines (Basel). 2024 Aug 2;12(8):876. doi: 10.3390/vaccines12080876.
Tuberculosis (TB) is an ancient global public health problem. Several strategies have been applied to develop new and more effective vaccines against TB, from attenuated or inactivated mycobacteria to recombinant subunit or genetic vaccines, including viral vectors. This review aimed to evaluate patents filed between 2010 and 2023 for TB vaccine candidates. It focuses on viral vector-based strategies. A search was carried out in Espacenet, using the descriptors "mycobacterium and tuberculosis" and the classification A61K39. Of the 411 patents preliminarily identified, the majority were related to subunit vaccines, with 10 patents based on viral vector platforms selected in this study. Most of the identified patents belong to the United States or China, with a concentration of patent filings between 2013 and 2023. Adenoviruses were the most explored viral vectors, and the most common immunodominant (Mtb) antigens were present in all the selected patents. The majority of patents were tested in mouse models by intranasal or subcutaneous route of immunization. In the coming years, an increased use of this platform for prophylactic and/or therapeutic approaches for TB and other diseases is expected. Along with this, expanding knowledge about the safety of this technology is essential to advance its use.
结核病是一个古老的全球公共卫生问题。为研发新型、更有效的抗结核疫苗,人们已应用了多种策略,从减毒或灭活分枝杆菌到重组亚单位疫苗或基因疫苗,包括病毒载体疫苗。本综述旨在评估2010年至2023年期间提交的针对结核候选疫苗的专利。它聚焦于基于病毒载体的策略。在欧洲专利局专利数据库(Espacenet)中进行了检索,使用的描述词为“分枝杆菌和结核病”以及分类号A61K39。在初步确定的411项专利中,大多数与亚单位疫苗相关,本研究选择了10项基于病毒载体平台的专利。大多数已确定的专利属于美国或中国,专利申请集中在2013年至2023年期间。腺病毒是研究最多的病毒载体,所有选定专利中均存在最常见的免疫显性结核分枝杆菌(Mtb)抗原。大多数专利在小鼠模型中通过鼻内或皮下免疫途径进行了测试。预计在未来几年,该平台将更多地用于结核病及其他疾病的预防和/或治疗方法。与此同时,扩大对该技术安全性的了解对于推进其应用至关重要。