Atalay Nur, Balci Nur, Gürsoy Mervi, Gürsoy Ulvi Kahraman
Department of Periodontology, Institute of Dentistry, University of Turku, Lemminkäisenkatu 2, 20520 Turku, Finland.
Department of Periodontology, Faculty of Dentistry, Medipol University, Goztepe Mahallesi, Ataturk Caddesi 40, Beykoz, 34815 Istanbul, Turkey.
Pathogens. 2024 Aug 2;13(8):654. doi: 10.3390/pathogens13080654.
Human beta-defensins are host defense peptides with broad antimicrobial and inflammatory functions. In the oral cavity, these peptides are produced mainly by the keratinocytes of the epithelium; however, fibroblasts, monocytes, and macrophages also contribute to oral human beta-defensin expressions. The resident and immune cells of the oral cavity come into contact with various microbe-associated molecular patterns continuously and simultaneously. The overall antimicrobial cellular response is highly influenced by local and environmental factors. Recent studies have produced evidence showing that not only systemic chronic diseases but also systemic factors like hyperglycemia, pregnancy, the long-term use of certain vitamins, and aging can modulate oral cellular antimicrobial responses against microbial challenges. Therefore, the aim of this narrative review is to discuss the role of systemic factors on oral human beta-defensin expressions.
人β-防御素是具有广泛抗菌和炎症功能的宿主防御肽。在口腔中，这些肽主要由上皮角质形成细胞产生；然而，成纤维细胞、单核细胞和巨噬细胞也参与口腔人β-防御素的表达。口腔中的常驻细胞和免疫细胞持续且同时地接触各种微生物相关分子模式。整体抗菌细胞反应受到局部和环境因素的高度影响。最近的研究已产生证据表明，不仅系统性慢性疾病，而且高血糖、妊娠、某些维生素的长期使用以及衰老等系统性因素都可调节口腔细胞对微生物挑战的抗菌反应。因此，本叙述性综述的目的是讨论系统性因素对口腔人β-防御素表达的作用。
