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基于菊粉两亲共聚物的药物递送：解析接枝结构的结构特征。

Inulin Amphiphilic Copolymer-Based Drug Delivery: Unraveling the Structural Features of Graft Constructs.

作者信息

Sardo Carla, Auriemma Giulia, Mazzacano Carmela, Conte Claudia, Piccolo Virgilio, Ciaglia Tania, Denel-Bobrowska Marta, Olejniczak Agnieszka B, Fiore Donatella, Proto Maria Chiara, Gazzerro Patrizia, Aquino Rita Patrizia

机构信息

Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy.

Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Napoli, Italy.

出版信息

Pharmaceutics. 2024 Jul 23;16(8):971. doi: 10.3390/pharmaceutics16080971.

DOI:10.3390/pharmaceutics16080971
PMID:39204316
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11359108/
Abstract

In this study, the structural attributes of nanoparticles obtained by a renewable and non-immunogenic "inulinated" analog of the "pegylated" PLA (PEG-PLA) were examined, together with the potential of these novel nanocarriers in delivering poorly water-soluble drugs. Characterization of INU-PLA assemblies, encompassing critical aggregation concentration (CAC), NMR, DLS, LDE, and SEM analyses, was conducted to elucidate the core/shell architecture of the carriers and in vitro cyto- and hemo-compatibility were assayed. The entrapment and in vitro delivery of sorafenib tosylate () were also studied. INU-PLA copolymers exhibit distinctive features: (1) Crew-cut aggregates are formed with coronas of 2-4 nm; (2) a threshold surface density of 1 INU/nm triggers a configuration change; (3) INU surface density influences PLA core dynamics, with hydrophilic segment stretching affecting PLA distribution towards the interface. INU-PLA demonstrated an outstanding loading of and excellent biological profile, with effective internalization and delivery to HepG2 cells, yielding a comparable IC.

摘要

在本研究中，我们研究了通过可再生且无免疫原性的“聚乙二醇化”聚乳酸（PEG-PLA）的“菊粉化”类似物获得的纳米颗粒的结构属性，以及这些新型纳米载体在递送难溶性药物方面的潜力。对包含临界聚集浓度（CAC）、核磁共振（NMR）、动态光散射（DLS）、低温电子显微镜（LDE）和扫描电子显微镜（SEM）分析的菊粉-聚乳酸（INU-PLA）组装体进行了表征，以阐明载体的核/壳结构，并测定了体外细胞和血液相容性。还研究了甲苯磺酸索拉非尼（）的包封和体外递送情况。INU-PLA共聚物具有独特的特征：（1）形成具有2-4纳米冠层的平头聚集体；（2）每纳米1个INU的阈值表面密度会引发构象变化；（3）INU表面密度影响PLA核动力学，亲水性链段的伸展影响PLA向界面的分布。INU-PLA表现出出色的包载量和优异的生物学特性，能有效地内化并将药物递送至HepG2细胞，产生相当的半数抑制浓度（IC）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa19/11359108/5222c21b0e14/pharmaceutics-16-00971-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa19/11359108/6c31cac0c05f/pharmaceutics-16-00971-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa19/11359108/21541993ffc9/pharmaceutics-16-00971-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa19/11359108/00c3862c4f3f/pharmaceutics-16-00971-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa19/11359108/15504f7afe64/pharmaceutics-16-00971-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa19/11359108/df5620a8b5eb/pharmaceutics-16-00971-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa19/11359108/ef04bb186f56/pharmaceutics-16-00971-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa19/11359108/307207791a7c/pharmaceutics-16-00971-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa19/11359108/5222c21b0e14/pharmaceutics-16-00971-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa19/11359108/6c31cac0c05f/pharmaceutics-16-00971-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa19/11359108/21541993ffc9/pharmaceutics-16-00971-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa19/11359108/00c3862c4f3f/pharmaceutics-16-00971-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa19/11359108/15504f7afe64/pharmaceutics-16-00971-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa19/11359108/df5620a8b5eb/pharmaceutics-16-00971-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa19/11359108/ef04bb186f56/pharmaceutics-16-00971-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa19/11359108/307207791a7c/pharmaceutics-16-00971-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa19/11359108/5222c21b0e14/pharmaceutics-16-00971-g007.jpg

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本文引用的文献

1
3D printed macroporous scaffolds of PCL and inulin-g-P(D,L)LA for bone tissue engineering applications.用于骨组织工程应用的 PCL 和菊粉-g-P(D,L)LA 的 3D 打印大孔支架。
Int J Pharm. 2023 Jun 25;641:123093. doi: 10.1016/j.ijpharm.2023.123093. Epub 2023 May 31.
2
Stealth nanoparticles in oncology: Facing the PEG dilemma.肿瘤学中的隐形纳米颗粒：面临 PEG 困境。
J Control Release. 2022 Nov;351:22-36. doi: 10.1016/j.jconrel.2022.09.002. Epub 2022 Sep 19.
3
Inulin-g-poly-D,L-lactide, a sustainable amphiphilic copolymer for nano-therapeutics.
菊粉-g-聚（D,L-丙交酯），一种用于纳米治疗的可持续性两亲性共聚物。
Drug Deliv Transl Res. 2022 Aug;12(8):1974-1990. doi: 10.1007/s13346-022-01135-4. Epub 2022 Feb 22.
4
Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery.聚乙二醇对靶向药物递送纳米粒子表面的影响。
Nanoscale. 2021 Jun 28;13(24):10748-10764. doi: 10.1039/d1nr02065j. Epub 2021 Jun 16.
5
Synthesis, Characterization, and Nanodisc Formation of Non-ionic Polymers*.非离子聚合物的合成、表征及纳米盘形成*
Angew Chem Int Ed Engl. 2021 Jul 26;60(31):16885-16888. doi: 10.1002/anie.202101950. Epub 2021 Jun 28.
6
Hepatocellular carcinoma.肝细胞癌。
Nat Rev Dis Primers. 2021 Jan 21;7(1):6. doi: 10.1038/s41572-020-00240-3.
7
Inulin-pluronic-stearic acid based double folded nanomicelles for pH-responsive delivery of resveratrol.基于菊粉-泊洛沙姆-硬脂酸的双折叠纳米胶束用于响应 pH 值的白藜芦醇递药系统。
Carbohydr Polym. 2020 Nov 1;247:116730. doi: 10.1016/j.carbpol.2020.116730. Epub 2020 Jul 7.
8
In Vitro Release Study of the Polymeric Drug Nanoparticles: Development and Validation of a Novel Method.聚合物药物纳米颗粒的体外释放研究：一种新方法的开发与验证
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9
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10
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