Hadassah Medical Center, Jerusalem, Israel.
Washington University School of Medicine, Saint Louis, MO, USA.
J Hand Surg Asian Pac Vol. 2024 Oct;29(5):373-379. doi: 10.1142/S2424835524400034. Epub 2024 Aug 30.
Electrical stimulation has been integrated in recent decades into rehabilitation protocols following neuromuscular injuries. Existing literature supports the utilisation of prolonged or continuous stimulation generated by implantable or transcutaneous devices for chronic pain subsidence and muscle trophism maintenance, which improve outcomes following microsurgical interventions. Newer uses include brief electrical stimulation for peripheral nerve injury. Brief electrical stimulation has shown promise in expediting regeneration of both torn and crushed nerve axons in the murine model and has been incorporated into a limited number of clinical studies. Augmentation of the natural response of an injured peripheral nerve by electrical stimulation has the potential to accelerate regeneration, presumably leading to improved function and clinical outcomes. We review the existing literature on intraoperative utilisation of electrical stimulation to enhance regeneration, such as neural mechanisms of action and their microscopic effect in animal models, as well as results from initial human studies. Level V (Therapeutic).
近几十年来，电刺激已被整合到神经肌肉损伤后的康复方案中。现有文献支持使用可植入或经皮设备产生的长时间或连续刺激来缓解慢性疼痛和维持肌肉营养，这可以改善显微手术干预后的结果。较新的用途包括短暂的电刺激治疗周围神经损伤。在小鼠模型中，短暂的电刺激已显示出在加速撕裂和压碎的神经轴突再生方面的前景，并已被纳入少数临床研究中。通过电刺激增强受伤周围神经的自然反应有加速再生的潜力，可能导致功能改善和临床结果的改善。我们回顾了关于术中使用电刺激来增强再生的现有文献，例如神经作用机制及其在动物模型中的微观作用，以及初步人体研究的结果。 5 级（治疗）。
