大鼠脑中促甲状腺激素释放激素（TRH）的发育变化。

Developmental changes of thyroliberin (TRH) in the rat brain.

作者信息

Nemeskéri A, Grouselle D, Faivre-Bauman A, Tixier-Vidal A

出版信息

Neurosci Lett. 1985 Feb 4;53(3):279-84. doi: 10.1016/0304-3940(85)90551-8.

PMID:3920581

Abstract

Levels of thyroliberin (TRH) were measured by radioimmunoassay in the hypothalamus and in the extrahypothalamic brain tissue of rats from fetal day 12 up to day 47 of postnatal life. TRH was detectable as early as on day 12 of intrauterine life in both the hypothalamic primordia and the extrahypothalamic brain tissue. The increase of hypothalamic TRH content was marked between fetal days 12 and 15, then up to the end of gestation it exhibited a slower tendency of increase. From fetal day 15 up to postnatal day 2 the TRH content of the hypothalamus was always higher than that of the extrahypothalamic brain. Both hypothalamic and extrahypothalamic TRH content increased up to day 35 of postnatal life.

摘要

采用放射免疫分析法，测定了从胚胎第12天直至出生后第47天大鼠下丘脑及下丘脑外脑组织中促甲状腺激素释放激素（TRH）的水平。早在胚胎期第12天，在下丘脑原基和下丘脑外脑组织中就可检测到TRH。下丘脑TRH含量在胚胎第12天至15天显著增加，然后直至妊娠末期，其增加趋势较为缓慢。从胚胎第15天直至出生后第2天，下丘脑的TRH含量始终高于下丘脑外脑组织。下丘脑和下丘脑外的TRH含量在出生后第35天前均有所增加。