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儿童药物相关副作用的危险因素:一项范围综述

Risk Factors Associated With Drug-Related Side Effects in Children: A Scoping Review.

作者信息

Toni Esmaeel, Ayatollahi Haleh, Abbaszadeh Reza, Fotuhi Siahpirani Alireza

机构信息

Iran University of Medical Sciences, Tehran, Iran.

University of Tehran, Tehran, Iran.

出版信息

Glob Pediatr Health. 2024 Aug 27;11:2333794X241273171. doi: 10.1177/2333794X241273171. eCollection 2024.

Abstract

. Children's vulnerability to drug-related side effects has been highlighted in several studies. However, there is no consensus on the risk factors associated with these side effects. This study aimed to investigate risk factors associated with drug-related side effects in children. . This scoping review was conducted across multiple databases. The search strategy was created with a focus on drug-related side effects, as they are more predictable based on the pre-determined risk factors. Data were collected, and reported narratively. . The demographic, health, hospital, and drug-related risk factors may cause drug-related side effects in children. Among them, low age, sex, polypharmacy, length of hospitalization, and medications used for comorbidities may increase the risk. . While most of the risk factors might be similar in adults and children, their impact might be different in these 2 groups. Therefore, future studies should identify more details about the impact of the risk factors in children.

摘要

多项研究强调了儿童对药物相关副作用的易感性。然而,对于与这些副作用相关的风险因素尚无共识。本研究旨在调查儿童药物相关副作用的风险因素。 本范围综述在多个数据库中进行。搜索策略的制定重点是药物相关副作用,因为基于预先确定的风险因素,它们更具可预测性。收集了数据并进行了叙述性报告。 人口统计学、健康、医院和药物相关的风险因素可能导致儿童出现药物相关副作用。其中,低年龄、性别、联合用药、住院时间和用于合并症的药物可能会增加风险。 虽然大多数风险因素在成人和儿童中可能相似,但它们在这两组中的影响可能不同。因此,未来的研究应确定有关风险因素对儿童影响的更多细节。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74c4/11350535/171e3945119c/10.1177_2333794X241273171-fig1.jpg

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