Razavianzadeh Nasrin, Shahramirad Soheil, Hasani Mohammad, Babaei Hessamedin
Department of Medical Sciences, Shahrood Branch Islamic Azad University Shahrood Iran.
Student Research Committee, Shahrood Branch Islamic Azad University Shahrood Iran.
Clin Case Rep. 2024 Aug 27;12(9):e9364. doi: 10.1002/ccr3.9364. eCollection 2024 Sep.
Paget's disease of bone (PDB) is a chronic condition causing abnormal bone remodeling, leading to pain, fractures, and complications. A 57-year-old female patient, asymptomatic and devoid of pain, incidentally exhibited elevated levels of alkaline phosphatase. Following a thorough consideration of potential differential diagnoses, the eventual diagnosis established was PDB. We recommended Fosamax (70 mg alendronate tablets) at two tablets twice weekly for 3 months to manage PDB due to patient preference and side effects with intravenous zoledronic acid. Subsequent assessments of alkaline phosphatase levels during follow-up examinations post-treatment revealed a reduction in their values.
骨佩吉特病（PDB）是一种导致异常骨重塑的慢性疾病，可引发疼痛、骨折及并发症。一名57岁女性患者，无症状且无疼痛，偶然发现碱性磷酸酶水平升高。在全面考虑了潜在的鉴别诊断后，最终确诊为PDB。由于患者偏好及静脉注射唑来膦酸的副作用，我们推荐使用福善美（阿仑膦酸钠片70毫克），每周两次，每次两片，共服用3个月来治疗PDB。治疗后随访检查期间对碱性磷酸酶水平的后续评估显示其值有所降低。
