State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University (GMU) - Guangzhou Institutes of Biomedicine and Health (GIBH) Joint School of Life Sciences, Guangzhou Medical University, Guangzhou, Guangdong, China.
Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong, China.
Front Immunol. 2024 Aug 14;15:1445372. doi: 10.3389/fimmu.2024.1445372. eCollection 2024.
Macrophages in the innate immune system play a vital role in various lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), acute lung injury and pulmonary fibrosis. Macrophages involved in the process of immunity need to go through a process of activation, including changes in gene expression and cell metabolism. Epigenetic modifications are key factors of macrophage activation including DNA methylation, histone modification and non-coding RNA regulation. Understanding the role and mechanisms of epigenetic regulation of macrophage activation can provide insights into the function of macrophages in lung diseases and help identification of potential therapeutic targets. This review summarizes the latest progress in the epigenetic changes and regulation of macrophages in their development process and in normal physiological states, and the epigenetic regulation of macrophages in COPD as well as the influence of macrophage activation on COPD development.
固有免疫系统中的巨噬细胞在各种肺部疾病中发挥着至关重要的作用，如哮喘、慢性阻塞性肺疾病（COPD）、急性肺损伤和肺纤维化。参与免疫过程的巨噬细胞需要经历一个激活过程，包括基因表达和细胞代谢的变化。表观遗传修饰是巨噬细胞激活的关键因素，包括 DNA 甲基化、组蛋白修饰和非编码 RNA 调控。了解表观遗传调控在巨噬细胞激活中的作用和机制可以深入了解巨噬细胞在肺部疾病中的功能，并有助于确定潜在的治疗靶点。本综述总结了巨噬细胞在发育过程中和正常生理状态下的表观遗传变化和调控，以及 COPD 中巨噬细胞的表观遗传调控和巨噬细胞激活对 COPD 发展的影响的最新进展。
