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金色植物化学物质对Notch信号通路的抑制作用：癌症治疗的潜力

Notch Signaling Suppression by Golden Phytochemicals: Potential for Cancer Therapy.

作者信息

Kaveh Zenjanab Masoumeh, Hashemzadeh Nastaran, Alimohammadvand Sajjad, Sharifi-Azad Masoumeh, Dalir Abdolahinia Elaheh, Jahanban-Esfahlan Rana

机构信息

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Adv Pharm Bull. 2024 Jul;14(2):302-313. doi: 10.34172/apb.2024.035. Epub 2024 Mar 10.

DOI:10.34172/apb.2024.035
PMID:39206407
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11347744/
Abstract

Cancer is one of the main causes of mortality worldwide. Cancer cells are characterized by unregulated cellular processes, including proliferation, progression, and angiogenesis. The occurrence of these processes is due to the dysregulation of various signaling pathways such as NF-κB (nuclear factor-κB), Wnt/beta-catenin, Notch signaling and MAPK (mitogen-activated protein kinases). Notch signaling pathways cause the progression of various types of malignant tumors. Among the phytochemicals for cancer therapy, several have attracted great interest, including curcumin, genistein, quercetin, silibinin, resveratrol, cucurbitacin and glycyrrhizin. Given the great cellular and molecular heterogeneity within tumors and the high toxicity and side effects of synthetic chemotherapeutics, natural products with pleiotropic effects that simultaneously target numerous signaling pathways appear to be ideal substitutes for cancer therapy. With this in mind, we take a look at the current status, impact and potential of known compounds as golden phytochemicals on key signaling pathways in tumors, focusing on the Notch pathway. This review may be useful for discovering new molecular targets for safe and efficient cancer therapy with natural chemotherapeutics.

摘要

癌症是全球主要死因之一。癌细胞的特征是细胞过程不受调控，包括增殖、进展和血管生成。这些过程的发生是由于多种信号通路失调，如核因子κB（NF-κB）、Wnt/β-连环蛋白、Notch信号通路和丝裂原活化蛋白激酶（MAPK）。Notch信号通路导致各种类型恶性肿瘤的进展。在用于癌症治疗的植物化学物质中，有几种引起了极大关注，包括姜黄素、染料木黄酮、槲皮素、水飞蓟宾、白藜芦醇、葫芦素和甘草甜素。鉴于肿瘤内存在巨大的细胞和分子异质性以及合成化疗药物的高毒性和副作用，具有多效性、同时靶向多种信号通路的天然产物似乎是癌症治疗的理想替代品。考虑到这一点，我们审视了已知化合物作为黄金植物化学物质对肿瘤关键信号通路的现状、影响和潜力，重点关注Notch通路。这篇综述可能有助于发现新的分子靶点，以便用天然化疗药物进行安全有效的癌症治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc3/11347744/b48fa831863d/apb-14-302-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc3/11347744/656967e0b3c2/apb-14-302-g009.jpg
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