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基于同情用药原则使用贝达喹啉治疗无眼球眼眶多药耐药感染:一例报告

Multidrug-resistant infection in an anophthalmic socket treated with bedaquiline on a compassionate use basis: A case report.

作者信息

Galindo-Rodríguez David, Moreno Hijazo Miguel, Balint Ilie Celina, Rubio Castro Daniel, Vallés Tormo Ignacio, Alias Alegre Eva Gloria

机构信息

Department of Internal Medicine, Hospital Obispo Polanco, Teruel, Spain.

Department of Medical Microbiology, Hospital Obispo Polanco, Teruel, Spain.

出版信息

Am J Ophthalmol Case Rep. 2024 Aug 8;36:102139. doi: 10.1016/j.ajoc.2024.102139. eCollection 2024 Dec.

DOI:10.1016/j.ajoc.2024.102139
PMID:39206414
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11357776/
Abstract

PURPOSE

To explore the management of a rare ophthalmic infection caused by a multi-resistant strain of in the anophthalmic cavity of a patient with a history of multiple eye surgeries.

OBSERVATIONS

A 60-year-old woman with a history of multiple ocular complications, culminating in the enucleation of the eye and subsequent dermograft implant, developed a resistant infection in the anophthalmic cavity. The infection persisted despite various local interventions and broad-spectrum systemic antibiotic treatments. Resolution of the infection was only achieved after precise diagnosis and the implementation of intensive treatment, which included a specific combination of antibiotics and appropriate surgical debridement of the anophthalmic cavity.

CONCLUSIONS AND IMPORTANCE

This case highlights the complexity in managing ophthalmic infections caused by non-tuberculous mycobacteria. It underscores the importance of a multidisciplinary and personalized treatment approach, as well as the need to develop specific guidelines for ophthalmic infections caused by rapidly growing mycobacteria.

摘要

目的

探讨一名有多次眼部手术史患者的无眼球眼眶内由多重耐药菌株引起的罕见眼部感染的管理方法。

观察结果

一名60岁女性,有多种眼部并发症病史,最终眼球摘除并植入皮肤移植片,其无眼球眼眶内发生耐药感染。尽管进行了各种局部干预和广谱全身抗生素治疗,感染仍持续存在。在精确诊断并实施强化治疗后感染才得以解决,强化治疗包括特定的抗生素组合和对无眼球眼眶进行适当的手术清创。

结论与重要性

本病例凸显了非结核分枝杆菌引起的眼部感染管理的复杂性。强调了多学科和个性化治疗方法的重要性,以及制定针对快速生长分枝杆菌引起的眼部感染的具体指南的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0393/11357776/e9bccc3684da/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0393/11357776/3a7491135c03/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0393/11357776/49b9fd5d6660/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0393/11357776/e9bccc3684da/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0393/11357776/3a7491135c03/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0393/11357776/49b9fd5d6660/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0393/11357776/e9bccc3684da/gr3.jpg

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Orbital and conjunctival nontuberculous mycobacteria infection.眼眶及结膜非结核分枝杆菌感染
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Treatment of Mycobacterium abscessus Pulmonary Disease.脓肿分枝杆菌肺病的治疗
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Differential Activities of Individual Drugs and Bedaquiline-Rifabutin Combinations against Actively Multiplying and Nutrient-Starved Mycobacterium abscessus.个别药物及贝达喹啉-利福布汀组合对处于活跃增殖期和营养饥饿期的脓肿分枝杆菌的差异活性
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Management of nontuberculous mycobacterial infections of the eye and orbit: A retrospective case series.眼部和眼眶非结核分枝杆菌感染的管理:一项回顾性病例系列研究。
Am J Ophthalmol Case Rep. 2020 Oct 21;20:100971. doi: 10.1016/j.ajoc.2020.100971. eCollection 2020 Dec.
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Rifabutin Is Bactericidal against Intracellular and Extracellular Forms of Mycobacterium abscessus.利福布汀对脓肿分枝杆菌的细胞内和细胞外形式均具有杀菌作用。
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