Walia Aditya, Kaur Amandeep, Singh Randhir, Rani Nidhi, Swami Rajan
Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Central University of Punjab, Bathinda, Punjab, India.
Cent Nerv Syst Agents Med Chem. 2025;25(2):91-108. doi: 10.2174/0118715249297247240813104929.
The most critical issue impeding the development of innovative cerebrospinal medications is the blood-brain barrier (BBB). The BBB limits the ability of most medications to penetrate the brain to the CNS. The BBB structure and functions are summarized, with the physical barrier generated by endothelial tight junctions and the transport barrier formed by transporters within the membrane and vesicular processes. The functions of connected cells, particularly the end feet of astrocytic glial cells, microglia, and pericytes, are described. The drugs that cross the blood brain barrier are explained below along with their mechanisms. Some of the associated conditions and problems are given.
阻碍创新型脑脊髓药物发展的最关键问题是血脑屏障（BBB）。血脑屏障限制了大多数药物穿透大脑进入中枢神经系统的能力。本文总结了血脑屏障的结构和功能，包括由内皮紧密连接产生的物理屏障以及由膜内转运体和囊泡运输过程形成的转运屏障。文中还描述了相关连接细胞的功能，特别是星形胶质细胞、小胶质细胞和周细胞的终足。下文将解释能够穿过血脑屏障的药物及其作用机制。同时也列举了一些相关病症和问题。
