Bhattacharya Tanima, Soares Giselle Amanda Borges E, Chopra Hitesh, Rahman Md Mominur, Hasan Ziaul, Swain Shasank S, Cavalu Simona
Innovation, Incubation & Industry (i-cube) Laboratory, Techno India NJR Institute of Technology, Udaipur 313003, India.
Department of Science & Engineering, Novel Global Community Educational Foundation, Hebersham, NSW 2770, Australia.
Materials (Basel). 2022 Jan 21;15(3):804. doi: 10.3390/ma15030804.
The strategies involved in the development of therapeutics for neurodegenerative disorders are very complex and challenging due to the existence of the blood-brain barrier (BBB), a closely spaced network of blood vessels and endothelial cells that functions to prevent the entry of unwanted substances in the brain. The emergence and advancement of nanotechnology shows favourable prospects to overcome this phenomenon. Engineered nanoparticles conjugated with drug moieties and imaging agents that have dimensions between 1 and 100 nm could potentially be used to ensure enhanced efficacy, cellular uptake, specific transport, and delivery of specific molecules to the brain, owing to their modified physico-chemical features. The conjugates of nanoparticles and medicinal plants, or their components known as nano phytomedicine, have been gaining significance lately in the development of novel neuro-therapeutics owing to their natural abundance, promising targeted delivery to the brain, and lesser potential to show adverse effects. In the present review, the promising application, and recent trends of combined nanotechnology and phytomedicine for the treatment of neurological disorders (ND) as compared to conventional therapies, have been addressed. Nanotechnology-based efforts performed in bioinformatics for early diagnosis as well as futuristic precision medicine in ND have also been discussed in the context of computational approach.
由于血脑屏障（BBB）的存在，神经退行性疾病治疗药物的研发策略非常复杂且具有挑战性。血脑屏障是由血管和内皮细胞组成的紧密网络，其作用是阻止有害物质进入大脑。纳米技术的出现和发展为克服这一现象带来了良好的前景。与药物部分和成像剂结合的工程纳米颗粒，尺寸在1到100纳米之间，由于其物理化学特性的改变，有可能用于提高疗效、促进细胞摄取、实现特定转运以及将特定分子递送至大脑。纳米颗粒与药用植物或其成分（即纳米植物药）的结合物，由于其天然丰富性、有望实现靶向脑递送以及不良反应潜力较小，最近在新型神经治疗药物的研发中变得越来越重要。在本综述中，与传统疗法相比，纳米技术与植物药联合用于治疗神经系统疾病（ND）的前景应用和最新趋势已得到阐述。在计算方法的背景下，还讨论了在生物信息学中基于纳米技术的早期诊断努力以及ND领域未来的精准医学。
