CD31对冠状动脉侧支循环发育的影响。

The Effect of CD31 on Coronary Collateral Development.

作者信息

Akcali Huseyin, Tascanov Mustafa Begenc, Toprak Kenan, Fedai Halil, Bicer Asuman, Altiparmak Ibrahim Halil, Tanriverdi Zulkif, Demirbag Recep, Koyuncu Ismail

机构信息

Department of Cardiology, Harran University, Faculty of Medicine, Sanliurfa, Turkiye.

Department of Biochemistry, Faculty of Medicine, Harran University, Sanliurfa, Turkiye.

出版信息

Cardiovasc Hematol Agents Med Chem. 2025;23(2):137-142. doi: 10.2174/0118715257300068240819071920.

DOI:10.2174/0118715257300068240819071920

PMID:39206488

Abstract

BACKGROUND

Coronary collaterals are the feeding bridges between the main epicardial arteries, and research has shown that this collateral development plays a crucial role in myocardial performance, especially in patients with coronary artery disease. However, the evolution of these collaterals has not been fully explained.

OBJECTIVES

In this study, we aimed to reveal the effect of CD31 on coronary collateral development.

METHODS

As a result of coronary angiography performed in our clinic, 89 patients with coronary artery disease and 90 patients with normal coronary arteries were included in the study. Collateral development degrees were recorded from the angiographic images of the subjects. CD31 values were compared between the group with coronary artery disease and the control group. In addition, the coronary artery disease group was divided into subgroups according to the collateral development in terms of good collateral development and poor collateral development, and the factors that may affect the collateral development were tried to be determined.

RESULTS

CD31 levels were significantly higher in the group with coronary artery disease compared to the control group (p <0.001). In addition, CD31 levels in the subgroup with good collateral were significantly higher than in the group with weak collateral (p <0.001). In the correlation analysis, a significant positive correlation was found between serum CD31 level and SYNTAX score, age, glucose, and rentrop grade. Multivariate logistic regression analysis showed CD31 to be an independent predictor of good coronary collateral development.

CONCLUSION

CD31, a marker of angiogenesis, may be involved in coronary collateral development.

摘要

背景

冠状动脉侧支是主要心外膜动脉之间的供血桥梁，研究表明这种侧支循环的发育在心肌功能中起着关键作用，尤其是在冠状动脉疾病患者中。然而，这些侧支的演变尚未得到充分解释。

目的

在本研究中，我们旨在揭示CD31对冠状动脉侧支发育的影响。

方法

根据在我们诊所进行的冠状动脉造影结果，89例冠状动脉疾病患者和90例冠状动脉正常患者被纳入研究。从受试者的血管造影图像中记录侧支发育程度。比较冠状动脉疾病组和对照组之间的CD31值。此外，冠状动脉疾病组根据侧支发育情况分为侧支发育良好和侧支发育不良的亚组，并试图确定可能影响侧支发育的因素。

结果

冠状动脉疾病组的CD31水平显著高于对照组（p<0.001）。此外，侧支良好亚组的CD31水平显著高于侧支较弱亚组（p<0.001）。在相关性分析中，血清CD31水平与SYNTAX评分、年龄、血糖和Rentrop分级之间存在显著正相关。多因素逻辑回归分析显示CD31是冠状动脉侧支发育良好的独立预测因子。