Department of Surgery, Dhulikhel Hospital, Kathmandu University Hospital, Kathmandu University School of Medical Sciences, Dhulikhel, Kavre, Nepal.
Research and Development Division, Dhulikhel Hospital, Kathmandu University Hospital, Kathmandu University School of Medical Sciences, Dhulikhel, Kavre, Nepal.
Kathmandu Univ Med J (KUMJ). 2023 Jul-Sep;21(83):270-274.
Background Acute appendicitis is one of the most common causes of acute abdomen requiring surgical treatment. Accurately diagnosing appendicitis and identifying complicated appendicitis can be difficult at times. Objective To evaluate the ability of the neutrophil-to-lymphocyte ratio (NLR) to differentiate between uncomplicated and complicated appendicitis. Method This was a prospective hospital-based observational study conducted at the Department of Surgery, Dhulikhel Hospital, Kathmandu University Hospital from July 2021 to December 2022. Patients with the clinical diagnosis of acute appendicitis who had undergone emergency appendectomy were included in the study. Informed consent was taken from each patient and data collection was done by filling the proforma. Result A total of 218 patients were included in the study. Male: female ratio was 1.18:1. Mean age of patients was 28.58 ± 16.65 (3-78) years. A significant correlation was found between increasing neutrophil count and neutrophil-to-lymphocyte ratio with complicated appendicitis. However, no significant correlation was found between White Blood Cell counts and complicated appendicitis. Neutrophil-to-lymphocyte ratio > 12.6 was found to be associated with complicated appendicitis. Conclusion A simple, cost-effective, and yet perfect test is not available for identifying complicated appendicitis. Increased Neutrophil count and neutrophil-to-lymphocyte ratio can indicate complicated appendicitis. Elevated WBC counts alone has no role in differentiating complicated appendicitis. According to the results of our study, an neutrophil-to-lymphocyte ratio of 12.6 can help to differentiate complicated from uncomplicated appendicitis.
急性阑尾炎是最常见的需要手术治疗的急腹症之一。准确诊断阑尾炎和识别复杂阑尾炎有时可能具有挑战性。目的：评估中性粒细胞与淋巴细胞比值（NLR）区分单纯性和复杂性阑尾炎的能力。方法：这是一项在 2021 年 7 月至 2022 年 12 月期间在加德满都大学医院 Dhulikhel 医院外科进行的前瞻性基于医院的观察性研究。研究纳入了接受急诊阑尾切除术的临床诊断为急性阑尾炎的患者。每位患者均获得知情同意，并通过填写表格进行数据收集。结果：共有 218 名患者纳入研究。男女比例为 1.18:1。患者的平均年龄为 28.58 ± 16.65（3-78）岁。与复杂阑尾炎相关的是，中性粒细胞计数和中性粒细胞与淋巴细胞比值的增加之间存在显著相关性。然而，白细胞计数与复杂阑尾炎之间没有显著相关性。中性粒细胞与淋巴细胞比值>12.6 与复杂阑尾炎相关。结论：目前尚无简单、经济有效且完美的测试方法可用于识别复杂阑尾炎。增加的中性粒细胞计数和中性粒细胞与淋巴细胞比值可提示复杂阑尾炎。单独升高的白细胞计数在区分复杂阑尾炎方面没有作用。根据我们的研究结果，中性粒细胞与淋巴细胞比值为 12.6 可以帮助区分单纯性和复杂性阑尾炎。
