Liu Yuheng, Huang Junfeng, Zhong Shuxin, Zheng Ziwen, Xu Zhixing, Zhou Dongda, Xie Shuojia, Lin Zikai, Li Shiyue, Chen Ruchong
Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine.
Department of Allergy and Clinical Immunology, The First Affiliated Hospital of Guangzhou Medical University.
Int J Surg. 2025 Jan 1;111(1):1348-1356. doi: 10.1097/JS9.0000000000001998.
Gastroesophageal reflux disease (GERD) is a prevalent condition that manifests a spectrum of symptoms, including gastroesophageal-related cough (GERC). Antireflux procedures have been employed to alleviate these symptoms, yet their efficacy varies. This systematic review and meta-analysis aim to evaluate the improvement in gastroesophageal-related cough and other reflux symptoms following antireflux procedures.
A systematic review was performed by searching PubMed, Embase, and Cochrane Library. All observational studies reporting the improvement of GERC and other reflux symptoms after the antireflux procedures. Data were extracted and pooled using a random effects model to assess the overall effect size and heterogeneity between studies. The authors found that antireflux surgery has some clear benefits for common reflux-related symptoms.
Fifty-nine eligible studies with 7431 patients with GERD were included in this study. The pooled cough remission rate was 80.0% (95% CI: 75.4-84.2) and the mean time of follow-up was 35.8 months. Antireflux surgery significantly improved overall reflux-related symptom scores (all P <0.001). The authors also assessed the rate of remission of other reflux symptoms. The pooled heartburn remission rate was 87.7% (95% CI: 82.3-92.2) and the pooled regurgitation remission rate was 91.2% (95% CI: 87.8-94.1).
Antireflux procedures significantly improve gastroesophageal-related cough and other reflux symptoms. These findings support the use of antireflux procedures as a viable treatment option for patients with GERD symptoms. Further research is needed to identify predictors of success and to optimize patient selection for antireflux procedures.
胃食管反流病（GERD）是一种常见疾病，表现出一系列症状，包括与胃食管相关的咳嗽（GERC）。抗反流手术已被用于缓解这些症状，但其疗效各不相同。本系统评价和荟萃分析旨在评估抗反流手术后与胃食管相关的咳嗽及其他反流症状的改善情况。
通过检索PubMed、Embase和Cochrane图书馆进行系统评价。所有观察性研究均报告了抗反流手术后GERC和其他反流症状的改善情况。使用随机效应模型提取和汇总数据，以评估总体效应大小和研究间的异质性。作者发现抗反流手术对常见的反流相关症状有一些明显的益处。
本研究纳入了59项符合条件的研究，共7431例GERD患者。汇总的咳嗽缓解率为80.0%（95%CI：75.4 - 84.2），平均随访时间为35.8个月。抗反流手术显著改善了总体反流相关症状评分（所有P<0.001）。作者还评估了其他反流症状的缓解率。汇总的烧心缓解率为87.7%（95%CI：82.3 - 92.2），汇总的反流缓解率为91.2%（95%CI：87.8 - 94.1）。
抗反流手术显著改善了与胃食管相关的咳嗽及其他反流症状。这些发现支持将抗反流手术作为GERD症状患者的一种可行治疗选择。需要进一步研究以确定成功的预测因素，并优化抗反流手术的患者选择。
Zotero 插件
