Department of Pharmaceutical Chemistry and Analysis, ISF College of Pharmacy, Moga, India.
Department of Pharmaceutics, ISF College of Pharmacy, Moga, India.
Expert Opin Ther Pat. 2024 Oct;34(10):1047-1072. doi: 10.1080/13543776.2024.2397732. Epub 2024 Aug 29.
Caspases are a family of protease enzymes that play a crucial role in apoptosis. Dysregulation of caspase activity has been implicated in various pathological conditions, making caspases an important focus of research in understanding cell death mechanisms and developing therapeutic strategies for diseases associated with abnormal apoptosis.
It is a comprehensive review of caspase inhibitors that have been comprising recently granted patents from 2016 to 2023. It includes peptide and non-peptide caspase inhibitors with their application for different diseases.
This review categorizes and analyses recently patented caspase inhibitors on various diseases. Diseases linked to caspase dysregulation, including neurodegenerative disorders, and autoimmune conditions, are highlighted to accentuate the therapeutic relevance of the patented caspase inhibitors. This paper serves as a valuable resource for researchers, clinicians, and pharmaceutical developers seeking an up-to-date understanding of recently patented caspase inhibitors. The integration of recent patented compounds, structural insights, and mechanistic details provides a holistic view of the progress in caspase inhibitor research and its potential impact on addressing various diseases.
Caspases 是一类在细胞凋亡中起关键作用的蛋白酶家族。Caspase 活性的失调与各种病理状况有关，因此 Caspases 成为研究细胞死亡机制和开发与异常细胞凋亡相关疾病治疗策略的重要焦点。
本文全面综述了 2016 年至 2023 年期间新获得专利的 Caspase 抑制剂。包括肽类和非肽类 Caspase 抑制剂及其在不同疾病中的应用。
本文对各种疾病的新专利 Caspase 抑制剂进行了分类和分析。重点介绍了与 Caspase 失调相关的疾病，包括神经退行性疾病和自身免疫性疾病，以强调专利 Caspase 抑制剂的治疗相关性。本文为研究人员、临床医生和药物开发者提供了宝贵的资源，帮助他们了解最新的 Caspase 抑制剂专利。综合近期专利化合物、结构见解和机制细节，为 Caspase 抑制剂研究的进展及其在解决各种疾病方面的潜力提供了全面的视角。
