Kaitin K I
Psychopharmacology (Berl). 1985;85(1):47-50. doi: 10.1007/BF00427320.
To test the hypothesis that sleep produced by thalidomide, unlike that of pentobarbital, is associated with increased neuronal activity in the preoptic area (POA), the spontaneous activity of 96 POA neurons was recorded in chronically prepared cats during alert wakefulness (W), deep slow-wave sleep (SWS), and REM sleep in a drug-free preparation and after administration of thalidomide (4 mg/kg) and pentobarbital (4 or 8 mg/kg). Thalidomide, unlike pentobarbital, at a dose that significantly increased the amount of SWS, failed to depress neuronal activity in the POA compared to drug-free controls. Mean discharge rates during thalidomide treatment were similar to drug-free rates. In contrast, rates during low-dose pentobarbital treatment were significantly less than those of drug-free and thalidomide-treated animals. Rates during high-dose pentobarbital treatment were significantly less than those in all other groups. Thalidomide, compared with the other groups, in addition to increasing the amount of SWS, significantly increased the total amount of REM sleep as well as REM sleep as a percent of total sleep, but did not produce ataxia or behavioral excitement. These results do not confirm the initial hypothesis, but suggest that hypnotic drugs that do not depress neuronal activity in the POA may be devoid of some of the unwanted side effects often associated with the more commonly prescribed hypnotic medications.
与戊巴比妥不同，沙利度胺产生的睡眠与视前区（POA）神经元活动增加有关，在长期制备的猫身上记录了96个POA神经元在清醒（W）、深度慢波睡眠（SWS）和快速眼动睡眠（REM）期间的自发活动，实验分为无药物处理组以及给予沙利度胺（4mg/kg）和戊巴比妥（4或8mg/kg）后。与戊巴比妥不同，沙利度胺在显著增加SWS量的剂量下，与无药物对照组相比，未能抑制POA中的神经元活动。沙利度胺治疗期间的平均放电率与无药物处理时相似。相比之下，低剂量戊巴比妥治疗期间的放电率显著低于无药物处理组和沙利度胺处理组的动物。高剂量戊巴比妥治疗期间的放电率显著低于所有其他组。与其他组相比，沙利度胺除了增加SWS量外，还显著增加了REM睡眠总量以及REM睡眠占总睡眠的百分比，但未产生共济失调或行为兴奋。这些结果并未证实最初的假说，但表明在POA中不抑制神经元活动的催眠药物可能没有一些通常与更常用的催眠药物相关的不良副作用。
