Castillo-Triana N, Camargo-Mendoza M
Universidad Nacional de Colombia, Bogotá DC, Colombia.
Rev Neurol. 2024 Sep 29;79(5):121-127. doi: 10.33588/rn.7905.2024108.
Parkinson's disease (PD) can affect the intelligibility of speech. Although studies of vowel production are useful for measuring this impairment, they do not exist in Spanish speakers with the disease who have been treated with subthalamic nucleus deep brain stimulation (STN-DBS). STN-DBS is an effective treatment for the classic signs of PD, but with varied effects on speech.
Data from two individuals with PD treated with STN-DBS were studied: one (P1) had impairment and the other (P2) had stable speech intelligibility after STN-DBS implantation. The triangular vowel space area (tVSA) and the vowel articulation index (VAI) were measured and compared before the implantation surgery, and at three, six and nine months after surgery. These measurements were compared with measurements of speech intelligibility (percentage of words correctly identified and degree of intelligibility).
Both participants presented variations in measurements of vowel articulation after surgery. In P1, the reduction in the tVSA, but not the post-surgical change in the VAI, was consistent with reduced speech intelligibility. However, in P2, both measurements (tVSA and VAI) reflected stable speech intelligibility after surgery.
Reduced speech intelligibility in Spanish speakers with PD after STN-DBS implantation may be reflected in a reduced tVSA.
帕金森病（PD）会影响言语清晰度。虽然元音发音的研究有助于衡量这种损伤，但针对接受丘脑底核深部脑刺激（STN-DBS）治疗的西班牙裔帕金森病患者的此类研究并不存在。STN-DBS是治疗帕金森病典型症状的有效方法，但对言语的影响各不相同。
研究了两名接受STN-DBS治疗的帕金森病患者的数据：一名患者（P1）存在损伤，另一名患者（P2）在植入STN-DBS后言语清晰度保持稳定。在植入手术前以及术后三个月、六个月和九个月测量并比较三角元音空间面积（tVSA）和元音清晰度指数（VAI）。将这些测量结果与言语清晰度的测量结果（正确识别单词的百分比和清晰度程度）进行比较。
两名参与者术后元音清晰度的测量结果均出现了变化。在P1中，tVSA的降低与言语清晰度的降低一致，但VAI的术后变化并非如此。然而，在P2中，两项测量结果（tVSA和VAI）均反映出术后言语清晰度保持稳定。
植入STN-DBS后，西班牙裔帕金森病患者言语清晰度降低可能表现为tVSA减小。
