运动、呼吸法和饮食联合对化疗成人癌症患者疲劳的影响：一项随机对照试验。
The combined effect of physical exercise, pranayama, and diet on fatigue in adult cancer patients undergoing chemotherapy: a randomized controlled trial.
机构信息
Department of Psycho-Oncology, HCG NCHRI Cancer Centre, Nagpur, 440026, Maharashtra, India.
Department of Nutrition and Dietetics, HCG NCHRI Cancer Center, Nagpur, 440026, Maharashtra, India.
出版信息
Support Care Cancer. 2024 Aug 29;32(9):618. doi: 10.1007/s00520-024-08821-8.
PURPOSE
Cancer patients undergoing chemotherapy continue to experience significant fatigue, which affects their quality of life. The present study aims to evaluate the combined effect of comprehensive physical exercise, pranayama (regulated breathing practices of yoga), and dietary support intervention on fatigue in cancer patients undergoing chemotherapy.
METHODS
Non-advanced adult cancer patients undergoing chemotherapy (N = 52) were randomized into the intervention group (N = 26) or control group (N = 26). Fatigue assessment was done using the Functional Assessment of Chronic Illness Therapy (FACIT) Fatigue Scale (version 4) at baseline and after 3 months. The intervention group participants practiced physical exercise, slow-paced pranayama and supplemented their diet with an intake of 100 g of millet protein powder (MPP), commonly known as "Sattu" in India. The control group received standard medical care.
RESULTS
A total of 39 patients (N = 13 in the intervention and N = 26 in the control group) were included in the statistical analysis. Within the intervention group, a statistically significant reduction in fatigue (p = 0.002) with a large effect size (d = 2.1) was observed. There was no statistically significant reduction in fatigue within the control group (p = 0.36). The group comparison showed a statistically significant reduction in post-scores of fatigue (p < 0.0001) in the intervention group as compared to the control group with a moderate effect size (R = 0.1). No unintended adverse effects related to the intervention were observed.
CONCLUSION
The results suggest the potential role of integrated physical exercise, pranayama, and dietary support in reducing fatigue in cancer patients undergoing chemotherapy. Further validation with a larger sample size is required.
TRIAL REGISTRATION
CTRI/2022/04/041717 [Registered prospectively on 07/04/2022].
目的
接受化疗的癌症患者仍会经历严重的疲劳，这会影响他们的生活质量。本研究旨在评估综合身体锻炼、呼吸练习（瑜伽的调节呼吸练习）和饮食支持干预对接受化疗的癌症患者疲劳的联合影响。
方法
将非晚期成年癌症患者（N=52）随机分为干预组（N=26）或对照组（N=26）。在基线和 3 个月后，使用慢性病治疗功能评估（FACIT）疲劳量表（第 4 版）评估疲劳。干预组参与者进行身体锻炼、慢节奏呼吸练习，并补充 100 克小米蛋白粉（MPP），俗称印度的“Sattu”。对照组接受标准医疗护理。
结果
共有 39 名患者（干预组 N=13，对照组 N=26）纳入统计分析。在干预组中，疲劳明显减轻（p=0.002），效果量较大（d=2.1）。对照组疲劳无明显减轻（p=0.36）。组间比较显示，干预组疲劳后评分显著降低（p<0.0001），效果中等（R=0.1），与对照组相比。未观察到与干预相关的意外不良反应。
结论
结果表明综合身体锻炼、呼吸练习和饮食支持在减轻接受化疗的癌症患者的疲劳方面具有潜在作用。需要更大样本量的进一步验证。
试验注册
CTRI/2022/04/041717[于 2022 年 4 月 7 日前瞻性注册]。
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