Department of Neurosurgery, Copenhagen University Hospital, Copenhagen, Denmark.
Department of Oncology, Hospital of Herlev and Gentofte, Herlev, Denmark.
Acta Neurochir (Wien). 2024 Aug 29;166(1):354. doi: 10.1007/s00701-024-06241-5.
This 13-year consecutive case series aims to provide a comprehensive overview of all patients operated for clival chordomas and clival chondrosarcomas in Denmark since the centralization of treatment in 2010, comparing outcomes to international series.
This was a retrospective review of 33 patients with clival tumors, comprising 22 chordomas and 11 chondrosarcomas, who were treated at Copenhagen University Hospital between years 2010 and 2023. Data were collected from digital patient records and pathology reports.
The symptoms leading to diagnosis primarily included double vision, headaches, and dizziness. In general, patients were in good health, with a mean Charlson Comorbidity Index score of 1.6. The complication rate of the index surgery was 51.5%. Adjuvant radiotherapy was applied in 51.5% of the cases. In patients with clival chordomas, the mean age was 51.1 years, ranging from 16 to 83 years. At the time of diagnosis, the mean tumor volume was 20.9 cm and the five-year overall survival rates were 79.1% (95% confidence interval (CI): 62.4-100). In patients with chondrosarcomas, the mean age was 48.2 years, ranging from 15 to 76 years. At the time of diagnosis, the mean tumor volume was 22.3 cm and the five-year overall survival 90% (95% CI: 73.2-100).
The centralized treatment of clival tumors in Denmark demonstrates incidence, survival, and complication rates comparable to those found in other international series. Given the variations in treatment strategies, tumor localizations across series, and small sample sizes, the further analysis of larger compiled multicenter datasets for clival tumors could provide more solid evidence regarding the management of these rare tumors.
本连续 13 年病例系列旨在提供自 2010 年治疗集中化以来丹麦所有接受颅底脊索瘤和软骨肉瘤手术患者的综合概述，将结果与国际系列进行比较。
这是对 2010 年至 2023 年期间在哥本哈根大学医院接受治疗的 33 例颅底肿瘤患者（包括 22 例脊索瘤和 11 例软骨肉瘤）的回顾性研究。数据从数字患者记录和病理报告中收集。
导致诊断的症状主要包括复视、头痛和头晕。一般来说，患者身体状况良好，Charlson 合并症指数平均得分为 1.6。主要手术的并发症发生率为 51.5%。51.5%的病例采用辅助放疗。颅底脊索瘤患者的平均年龄为 51.1 岁，年龄范围为 16 岁至 83 岁。诊断时，平均肿瘤体积为 20.9cm，五年总生存率为 79.1%（95%置信区间（CI）：62.4-100）。软骨肉瘤患者的平均年龄为 48.2 岁，年龄范围为 15 岁至 76 岁。诊断时，平均肿瘤体积为 22.3cm，五年总生存率为 90%（95%CI：73.2-100）。
丹麦对颅底肿瘤的集中治疗显示发病率、生存率和并发症发生率与其他国际系列相似。鉴于治疗策略、跨系列肿瘤定位以及样本量小的差异，进一步分析更大的颅底肿瘤汇总多中心数据集可以为这些罕见肿瘤的管理提供更可靠的证据。
