School of Kinesiology, University of British Columbia, 210-6081 University Boulevard, Vancouver, British Columbia, V6T 1Z1, Canada; International Collaboration On Repair Discoveries (ICORD), Vancouver Coastal Health Research Institute, 818 West 10(th) Avenue, Vancouver, British Columbia, V5Z 1M9, Canada.
International Collaboration On Repair Discoveries (ICORD), Vancouver Coastal Health Research Institute, 818 West 10(th) Avenue, Vancouver, British Columbia, V5Z 1M9, Canada; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 11228-2775 Laurel Street, Vancouver, British Columbia, Canada, V5Z 1M9.
Clin Neurophysiol. 2024 Oct;166:223-231. doi: 10.1016/j.clinph.2024.07.019. Epub 2024 Aug 7.
The purpose of this systematic review was to characterize methodologies reported in the literature to elicit and record pudendal somatosensory evoked potentials (SEPs) in human adults.
We conducted an electronic literature search in MEDLINE, Embase, CENTRAL, and CINAHL for studies that elicited pudendal SEPs via electrical stimulation and recorded responses though electroencephalography. From included studies, we extracted methodological details of how the SEPs were evoked and recorded.
132 studies were included in our review. The majority of participants were male (n = 6742/8526, 79%). Almost all studies stimulated the dorsal nerve of penis/clitoris. Stimulus parameters varied, with most standardizing stimulus intensity to 2-4x perceptual threshold, pulse duration to 0.1-0.2 ms, and frequency to 3 Hz. The number of stimuli recorded varied by clinical population.
Our results demonstrate the inconsistencies of pudendal SEP methodology in the literature, with the majority (77%) of publications not reporting enough detail to reasonably replicate their protocol. Most research to date has been conducted in males, highlighting the paucity of female pelvic neurophysiology research.
We propose a Pudendal SEP Reporting Checklist for adequate reporting of pudendal SEP protocols. Optimal sex- and patient-specific methodologies to investigate all branches of the pudendal nerve need to be established.
本系统评价旨在描述文献中报告的用于记录成人阴部躯体感觉诱发电位（SEP）的方法学。
我们对 MEDLINE、Embase、CENTRAL 和 CINAHL 进行了电子文献检索，以寻找通过电刺激诱发阴部 SEP 并通过脑电图记录反应的研究。从纳入的研究中，我们提取了诱发和记录 SEP 的方法学细节。
本综述共纳入 132 项研究。大多数参与者为男性（n=6742/8526，79%）。几乎所有研究均刺激阴茎/阴蒂背神经。刺激参数不同，大多数研究将刺激强度标准化为 2-4 倍感知阈值、脉冲持续时间为 0.1-0.2ms 以及频率为 3Hz。记录的刺激数量因临床人群而异。
我们的结果表明，文献中阴部 SEP 方法学存在不一致性，大多数（77%）出版物未报告足够的细节以合理复制其方案。迄今为止，大多数研究都在男性中进行，突出了女性盆腔神经生理学研究的匮乏。
我们提出了阴部 SEP 报告清单，以充分报告阴部 SEP 方案。需要建立最佳的性别和患者特异性方法来研究阴部神经的所有分支。
