School of Food Science and Technology, Hainan University, Hainan 570228, PR China; College of Food Science and Engineering, Ocean University of China, No.1299, San Sha Road, Qingdao, Shandong Province 266003, PR China.
College of Food Science and Engineering, Ocean University of China, No.1299, San Sha Road, Qingdao, Shandong Province 266003, PR China.
Food Chem. 2025 Jan 1;462:140961. doi: 10.1016/j.foodchem.2024.140961. Epub 2024 Aug 22.
The underlying toxicity mechanisms of microplastics on oysters have rarely been explored. To fill this gap, the present study investigated the metabolic profile and protein expression responses of oysters to microplastic stress through metabolomics and biochemical analyses. Oysters were exposed to microplastics for 21 days, and the results indicated that the microplastics induced oxidative stress, with a significant decrease in SOD activity in the 0.1 mg/L exposure group. Metabolomics revealed that exposure to microplastics disturbed many metabolic pathways, such as amino acid metabolism, lipid metabolism, biosynthesis of amino acids, aminoacyl-tRNA biosynthesis, and that different concentrations of microplastics induced diverse metabolomic profiles in oysters. Overall, the current study provides new reference data and insights for assessing food safety and consumer health risks caused by microplastic contamination.
微塑料对牡蛎的潜在毒性机制很少被探索。为了填补这一空白，本研究通过代谢组学和生化分析，研究了牡蛎对微塑料胁迫的代谢谱和蛋白质表达反应。牡蛎暴露于微塑料 21 天后，结果表明微塑料诱导了氧化应激，在 0.1mg/L 暴露组中 SOD 活性显著下降。代谢组学揭示，暴露于微塑料扰乱了许多代谢途径，如氨基酸代谢、脂质代谢、氨基酸生物合成、氨酰-tRNA 生物合成，并且不同浓度的微塑料在牡蛎中诱导了不同的代谢谱。总的来说，本研究为评估微塑料污染对食品安全和消费者健康风险提供了新的参考数据和见解。
