Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA; Pandemic Research Alliance Unit at the Wu Family Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Cell Rep Med. 2024 Sep 17;5(9):101701. doi: 10.1016/j.xcrm.2024.101701. Epub 2024 Aug 28.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing antibodies are substantially expanded 1 month after a shot of XBB.1.5 monovalent mRNA vaccine (XBB.1.5 MV) booster, but the durability of this response remains unknown. Here, we address this question by performing neutralization assays on four viral variants (D614G, BA.5, XBB.1.5, and JN.1) using sera from participants obtained at ∼1 month, ∼3 months, and ∼6 months post an XBB.1.5 MV booster. Our findings indicate that the resulting neutralizing antibody titers are robust and generally remain at stable levels for the study period, similar to those following XBB infection. Importantly, this durability of neutralizing antibody titers contrasts with the decline observed after a booster of the original monovalent or BA.5 bivalent mRNA vaccine. Our results are in line with the recent national data from the Centers for Disease Control and Prevention, showing that the efficacy against symptomatic SARS-CoV-2 infection is sustained for up to 4 months after an XBB.1.5 MV booster.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）中和抗体在接受 XBB.1.5 单价 mRNA 疫苗（XBB.1.5 MV）加强针注射后 1 个月显著增加，但这种反应的持久性仍不清楚。在这里，我们通过使用接种 XBB.1.5 MV 加强针后约 1 个月、3 个月和 6 个月采集的参与者的血清，对四种病毒变体（D614G、BA.5、XBB.1.5 和 JN.1）进行中和测定来解决这个问题。我们的研究结果表明，产生的中和抗体滴度是稳健的，在研究期间通常保持稳定水平，与 XBB 感染后的水平相似。重要的是，这种中和抗体滴度的持久性与原始单价或 BA.5 双价 mRNA 疫苗加强针后观察到的下降形成对比。我们的研究结果与疾病预防控制中心最近的全国数据一致，表明在接受 XBB.1.5 MV 加强针后，对有症状的 SARS-CoV-2 感染的疗效可持续长达 4 个月。
