Department of Biochemistry Afe Babalola University, PMB 5454, Ado-Ekiti, Nigeria.
Department of Biochemistry Afe Babalola University, PMB 5454, Ado-Ekiti, Nigeria.
Eur J Pharmacol. 2024 Nov 5;982:176958. doi: 10.1016/j.ejphar.2024.176958. Epub 2024 Aug 30.
Alzheimer's disease (AD) remains one of the most debilitating disease and most common neurological disorder in the world at large. However, with many years of multiple research and billions of dollars invested for the purpose of research, not many therapeutic options exist for the management of this disease. As at 2023, the number has only increased to 7, one of which is a combination of two existing therapies. However, research has continued still in the search for a cure. The roles and functions of thiamine, pyridoxine and cobalamin in the proper function of the nervous system has been well researched over time and their role in the management of neurological diseases have been of interest in the last decade. This review describes the roles of the aforementioned chemicals in the management of different models of AD and AD-like pathologies as mono-therapeutic agents and prospective adjuvant for combination therapy.
阿尔茨海默病（AD）仍然是世界上最具危害性的疾病和最常见的神经退行性疾病之一。然而，经过多年的大量研究和数十亿美元的投资，目前针对这种疾病的治疗方法并不多。截至 2023 年，仅有 7 种治疗方法，其中一种是两种现有疗法的组合。然而，研究仍在继续，以寻找治愈方法。随着时间的推移，硫胺素、吡哆醇和钴胺素在神经系统正常功能中的作用已经得到了很好的研究，它们在神经疾病管理中的作用在过去十年中引起了人们的兴趣。这篇综述描述了上述化学物质作为单一治疗药物和联合治疗的潜在辅助药物，在管理不同 AD 模型和 AD 样病理中的作用。
