Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
First School of Clinical Medicine, Anhui Medical University, Hefei 230032, China.
Gene. 2025 Jan 10;932:148896. doi: 10.1016/j.gene.2024.148896. Epub 2024 Aug 30.
Pescadillo ribosomal biogenesis factor 1 (PES1), a nucleolar protein initially identified in zebrafish, plays an important role in embryonic development and ribosomal biogenesis. Notably, PES1 has been found to be overexpressed in a number of cancer types, where it contributes to tumorigenesis and cancer progression by promoting cell proliferation, suppressing cellular senescence, modulating the tumor microenvironment (TME) and promoting drug resistance in cancer cells. Moreover, recent emerging evidence suggests that PES1 expression is significantly elevated in the livers of Type 2 diabetes mellitus (T2DM) and obese patients, indicating its involvement in the pathogenesis of metabolic diseases through lipid metabolism regulation. In this review, we present the structural characteristics and biological functions of PES1, as well as complexes in which PES1 participates. Furthermore, we comprehensively summarize the multifaceted role of PES1 in various diseases and the latest insights into its underlying molecular mechanisms. Finally, we discuss the potential clinical translational perspectives of targeting PES1, highlighting its promising as a therapeutic intervention and treatment target.
鱼胚核糖体生物发生因子 1（PES1）是一种最初在斑马鱼中发现的核仁蛋白，在胚胎发育和核糖体生物发生中发挥重要作用。值得注意的是，PES1 在许多癌症类型中过表达，通过促进细胞增殖、抑制细胞衰老、调节肿瘤微环境（TME）和促进癌细胞耐药性，促进肿瘤发生和癌症进展。此外，最近的新证据表明，PES1 的表达在 2 型糖尿病（T2DM）和肥胖患者的肝脏中显著升高，表明其通过脂质代谢调节参与代谢疾病的发病机制。在这篇综述中，我们介绍了 PES1 的结构特征和生物学功能，以及 PES1 参与的复合物。此外，我们全面总结了 PES1 在各种疾病中的多方面作用及其潜在的分子机制。最后，我们讨论了针对 PES1 的潜在临床转化观点，强调了其作为治疗干预和治疗靶点的广阔前景。
