Harnessing stem cell-based approaches for clinically meaningful discoveries in schizophrenia.
作者信息
Lizano Paulo, Karmacharya Rakesh
机构信息
Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Division Chief of Translational Neuroscience, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Chemical Biology Program, Broad Institute of MIT & Harvard, Cambridge, MA, USA; Schizophrenia & Bipolar Disorder Program, McLean Hospital, Belmont, MA, USA.
出版信息
Schizophr Res. 2024 Nov;273:1-3. doi: 10.1016/j.schres.2024.08.006. Epub 2024 Aug 29.
Abstract
摘要
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本文引用的文献
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Probing the biological consequences of a previously undescribed de novo mutation of ZMYND11 in a schizophrenia patient by CRISPR genome editing and induced pluripotent stem cell based in vitro disease-modeling.通过 CRISPR 基因组编辑和基于诱导多能干细胞的体外疾病建模探究精神分裂症患者中一个此前未描述的 ZMYND11 新生突变的生物学后果。
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Recapitulation of Perturbed Striatal Gene Expression Dynamics of Donors' Brains With Ventral Forebrain Organoids Derived From the Same Individuals With Schizophrenia.来自同一例精神分裂症个体的腹侧前脑类器官衍生的供体大脑纹状体基因表达动态紊乱的概述。
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