Institute of Clinical Chemistry, University Hospital of Zurich and University of Zurich, Zurich, Switzerland.
Institute of Clinical Chemistry, University Hospital of Zurich and University of Zurich, Zurich, Switzerland.
Atherosclerosis. 2024 Nov;398:118560. doi: 10.1016/j.atherosclerosis.2024.118560. Epub 2024 Aug 10.
Atherosclerotic cardiovascular diseases remain a leading cause of morbidity and mortality worldwide. Atherogenesis is a slow and life-long process characterized by the accumulation of lipoproteins and immune cells within the arterial wall. Atherosclerosis has been successfully modeled in animals: However, there are economic, ethical, and translational concerns when using these models. There is also growing recognition of the need for robust human-based in vitro systems that can faithfully recapitulate key aspects of human atherosclerosis. Such systems may offer advantages in terms of scalability, reproducibility, and ability to manipulate specific variables, thereby facilitating a deeper understanding of disease mechanisms and accelerating the development of targeted therapeutics. Leveraging innovative in vitro platforms holds promise in complementing traditional animal models of atherosclerosis. In the present review, we discuss the advantages and disadvantages of recently developed models of atherosclerosis and propose ideas to be considered when developing future generations of models.
动脉粥样硬化性心血管疾病仍然是全球发病率和死亡率的主要原因。动脉粥样硬化形成是一个缓慢且终身的过程，其特征是脂蛋白和免疫细胞在动脉壁内的积累。在动物中已经成功地模拟了动脉粥样硬化：然而，使用这些模型存在经济、伦理和转化方面的问题。人们越来越认识到需要可靠的基于人体的体外系统，这些系统可以忠实地再现人类动脉粥样硬化的关键方面。与传统的动脉粥样硬化动物模型相比，此类系统在可扩展性、可重复性和操纵特定变量的能力方面具有优势，从而有助于更深入地了解疾病机制并加速靶向治疗的发展。利用创新的体外平台有望补充传统的动脉粥样硬化动物模型。在本综述中，我们讨论了最近开发的动脉粥样硬化模型的优缺点，并提出了在开发新一代模型时需要考虑的想法。
