Akiyama S
Gan To Kagaku Ryoho. 1985 Mar;12(3 Pt 2):660-8.
Calcium antagonists, verapamil and D600, enhance the toxicity of EGF-PE and anti-TFR-PE. EGF and EGF-PE are accumulated in their intact form in the lysosomes of cells treated with D600 or verapamil. Verapamil and D600 decrease the activity of lysosomal enzymes, especially of cathepsin B. Verapamil may enhance the cytotoxicity of EGF-PE by blocking lysosomal degradation of EGF-PE.
钙拮抗剂维拉帕米和D600可增强表皮生长因子-PE（EGF-PE）和抗转铁蛋白受体-PE（anti-TFR-PE）的毒性。在经D600或维拉帕米处理的细胞溶酶体中，EGF和EGF-PE以完整形式积累。维拉帕米和D600降低溶酶体酶的活性，尤其是组织蛋白酶B的活性。维拉帕米可能通过阻断EGF-PE的溶酶体降解来增强其细胞毒性。
