Department of Pharmacology, Amity Institute of Pharmacy, Amity University (Lucknow Campus), Lucknow, Uttar Pradesh, 226010, India.
Mol Biol Rep. 2024 Aug 29;51(1):944. doi: 10.1007/s11033-024-09874-y.
Insulin resistance (IR) being the major cause behind different metabolic disorders, has attracted a lot of attention. Epidemiological data shows marked rise in the cases over a period of time. Nitric oxide (NO), produced from nitric oxide synthases (NOS), is involved in a variety of biological functions, alteration in which causes various disorders like hypertension, atherosclerosis, and angiogenesis-associated disorders. IR has been found to be a contributing factor, which is associated with abnormal NO signalling. Skeletal muscle is essential for metabolism, both for its role in glucose uptake and its importance in metabolic disease. In this article, we give an overview of the significance of NO in oxidative stress (OS) mediated IR, describing its role in different conditions that are associated with skeletal muscle IR. NO is found to be involved in the activation of insulin receptor downstream pathway, which suggests absence of NO could lead to reduced glucose uptake, and may ultimately result in IR.
胰岛素抵抗（IR）是多种代谢紊乱的主要原因，引起了广泛关注。流行病学数据显示，在一段时间内，病例数量明显上升。一氧化氮（NO）由一氧化氮合酶（NOS）产生，参与多种生物学功能，其改变会导致各种疾病，如高血压、动脉粥样硬化和血管生成相关疾病。IR 被发现是一种促成因素，与异常的 NO 信号有关。骨骼肌对于代谢非常重要，既是葡萄糖摄取的作用，也是代谢疾病的重要作用。在本文中，我们概述了 NO 在氧化应激（OS）介导的 IR 中的重要性，描述了它在与骨骼肌 IR 相关的不同情况下的作用。NO 被发现参与胰岛素受体下游途径的激活，这表明缺乏 NO 可能导致葡萄糖摄取减少，并可能最终导致 IR。
